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Arachidonic acid pathway alterations in cerebrospinal fluid of dogs with naturally occurring spinal cord injury

Overview of attention for article published in BMC Neuroscience, June 2016
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Title
Arachidonic acid pathway alterations in cerebrospinal fluid of dogs with naturally occurring spinal cord injury
Published in
BMC Neuroscience, June 2016
DOI 10.1186/s12868-016-0269-4
Pubmed ID
Authors

Rae L. Russell, Jonathan M. Levine, Nick D. Jeffery, Colin Young, Armando Mondragon, Bryan Lee, C. Elizabeth Boudreau, C. Jane Welsh, Gwendolyn J. Levine

Abstract

Canine intervertebral disc πherniation causes a naturally-occurring spinal cord injury (SCI) that bears critical similarities to human SCI with respect to both injury pathomechanisms and treatment. As such, it has tremendous potential to enhance our understanding of injury biology and the preclinical evaluation of novel therapies. Currently, there is limited understanding of the role of arachidonic acid metabolites in canine SCI. The CSF concentrations of PLA2 and PGE2 were higher in SCI dogs compared to control dogs (p = 0.0370 and 0.0273, respectively), but CSF LCT4 concentration in SCI dogs was significantly lower than that in control dogs (p < 0.0001). Prostaglandin E2 concentration in the CSF was significantly and positively associated with increased severity of SCI at the time of sampling (p = 0.041) and recovery 42 days post-injury (p = 0.006), as measured by ordinal behavioral scores. Arachidonic acid metabolism is altered in dogs with SCI, and these data suggest that these AA metabolites reflect injury severity and recovery, paralleling data from other model systems.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Unknown 35 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 25%
Student > Master 4 11%
Other 3 8%
Researcher 3 8%
Professor > Associate Professor 3 8%
Other 6 17%
Unknown 8 22%
Readers by discipline Count As %
Medicine and Dentistry 11 31%
Veterinary Science and Veterinary Medicine 4 11%
Neuroscience 3 8%
Nursing and Health Professions 2 6%
Social Sciences 2 6%
Other 5 14%
Unknown 9 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 July 2016.
All research outputs
#18,148,462
of 23,314,015 outputs
Outputs from BMC Neuroscience
#828
of 1,260 outputs
Outputs of similar age
#247,595
of 346,697 outputs
Outputs of similar age from BMC Neuroscience
#17
of 35 outputs
Altmetric has tracked 23,314,015 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,260 research outputs from this source. They receive a mean Attention Score of 4.4. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 346,697 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.