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Efficacy of fluralaner spot-on solution against induced infestations with Rhipicephalus sanguineus on dogs

Overview of attention for article published in Parasites & Vectors, May 2016
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Title
Efficacy of fluralaner spot-on solution against induced infestations with Rhipicephalus sanguineus on dogs
Published in
Parasites & Vectors, May 2016
DOI 10.1186/s13071-016-1523-4
Pubmed ID
Authors

Janina Taenzler, Julian Liebenberg, Machiel Mienie, William R. Everett, David R. Young, Thomas S. Vihtelic, Fangshi Sun, Eva Zschiesche, Rainer K. A. Roepke, Anja R. Heckeroth

Abstract

The efficacy of fluralaner spot-on solution administered once topically against induced infestations with Rhipicephalus sanguineus was evaluated in dogs over a 12-week post-treatment period. Six negative-controlled studies were conducted, involving a total of 112 adult dogs (57 mixed breed, 47 Beagles, eight Labradors). In each study, dogs were randomized to two groups of eight to ten dogs each. On day 0, dogs in each treated group were topically administered fluralaner spot-on solution once at a dose of 25 mg/kg body weight, while dogs in each control group were not treated. Two days before treatment, and on days 28, 56 and 84 after treatment, all dogs were infested with approximately 50 unfed, adult Rh. sanguineus ticks (sex ratio 1:1). Ticks were removed and counted on days 2, 30 (4 weeks), 58 (8 weeks), and 86 (12 weeks) after treatment to assess efficacy. Efficacy against ticks 2 days after treatment was 91.1 % (study 1), 98.4 % (study 2), 100 % (study 3), 97.6 % (study 4), 99.6 % (study 5), and 99.8 % (study 6). At all other assessment time points, tick efficacy was 95.4-100 %. Tick reduction in all treatment groups was significant at all assessment time points (P < 0.0001). A single topical administration of fluralaner spot-on solution provides a high level of therapeutic and persistent efficacy against Rh. sanguineus ticks over the subsequent 12 weeks.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 4%
Unknown 22 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 22%
Student > Ph. D. Student 3 13%
Student > Bachelor 2 9%
Student > Postgraduate 2 9%
Student > Master 2 9%
Other 2 9%
Unknown 7 30%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 5 22%
Agricultural and Biological Sciences 5 22%
Pharmacology, Toxicology and Pharmaceutical Science 2 9%
Medicine and Dentistry 2 9%
Unknown 9 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 June 2016.
All research outputs
#20,333,181
of 22,877,793 outputs
Outputs from Parasites & Vectors
#4,857
of 5,474 outputs
Outputs of similar age
#291,460
of 338,931 outputs
Outputs of similar age from Parasites & Vectors
#164
of 174 outputs
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So far Altmetric has tracked 5,474 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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