Title |
Centrally necrotizing breast carcinoma: a rare histological subtype, which was cause of misdiagnosis in an evident clinical local recurrence
|
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Published in |
World Journal of Surgical Oncology, August 2012
|
DOI | 10.1186/1477-7819-10-156 |
Pubmed ID | |
Authors |
Fernando Hernanz, Pilar Alonso-Bartolomé, Irene González-Rodilla |
Abstract |
Centrally necrotizing carcinoma is a rare subtype of breast carcinoma, which is characterized by an extensive central necrotic zone accounting for at least 70% of the cross-sectional area of the neoplasm. This central necrotic zone, in turn, is surrounded by a narrow rim of proliferative viable tumor cells. We report an unusual clinical situation in which a patient whose evident breast mass suggested an ipsilateral local recurrence and for which numerous attempts to confirm the histological diagnosis had failed. The patient was treated with a radical mastectomy based on clinical suspicion of breast cancer recurrence after an undesirable delay. In this case, the narrow rim of viable malignant tissue had a thickness of 0.5 to 8 mm, and the centrally necrotizing carcinoma had a central zone with a predominance of fibrosis. The special features of this case led to a misdiagnosis and to an evident clinical local recurrence. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 9 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 1 | 11% |
Student > Bachelor | 1 | 11% |
Student > Postgraduate | 1 | 11% |
Student > Master | 1 | 11% |
Unknown | 5 | 56% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 2 | 22% |
Agricultural and Biological Sciences | 1 | 11% |
Nursing and Health Professions | 1 | 11% |
Unknown | 5 | 56% |