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Role of aberrant metalloproteinase activity in the pro-inflammatory phenotype of bronchial epithelium in COPD

Overview of attention for article published in Respiratory Research, December 2011
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Title
Role of aberrant metalloproteinase activity in the pro-inflammatory phenotype of bronchial epithelium in COPD
Published in
Respiratory Research, December 2011
DOI 10.1186/1465-9921-12-110
Pubmed ID
Authors

Irene H Heijink, Simone M Brandenburg, Jacobien A Noordhoek, Dirk-Jan Slebos, Dirkje S Postma, Antoon J van Oosterhout

Abstract

Cigarette smoke, the major risk factor for COPD, is known to activate matrix metalloproteinases in airway epithelium. We investigated whether metalloproteinases, particularly A Disintegrin and Metalloproteinase (ADAM)17, contribute to increased pro-inflammatory epithelial responses with respect to the release of IL-8 and TGF-α, cytokines implicated in COPD pathogenesis.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Netherlands 1 3%
Unknown 28 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 23%
Researcher 6 20%
Other 3 10%
Student > Bachelor 3 10%
Lecturer 1 3%
Other 3 10%
Unknown 7 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 27%
Biochemistry, Genetics and Molecular Biology 6 20%
Medicine and Dentistry 5 17%
Nursing and Health Professions 1 3%
Immunology and Microbiology 1 3%
Other 1 3%
Unknown 8 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 August 2012.
All research outputs
#20,656,161
of 25,373,627 outputs
Outputs from Respiratory Research
#2,702
of 3,062 outputs
Outputs of similar age
#203,844
of 246,216 outputs
Outputs of similar age from Respiratory Research
#60
of 69 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,062 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one is in the 3rd percentile – i.e., 3% of its peers scored the same or lower than it.
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We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.