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Role of aberrant metalloproteinase activity in the pro-inflammatory phenotype of bronchial epithelium in COPD.

Overview of attention for article published in Respiratory Research, August 2011
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1 tweeter

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27 Mendeley
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Title
Role of aberrant metalloproteinase activity in the pro-inflammatory phenotype of bronchial epithelium in COPD.
Published in
Respiratory Research, August 2011
DOI 10.1186/1465-9921-12-110
Pubmed ID
Authors

Heijink IH, Brandenburg SM, Noordhoek JA, Slebos DJ, Postma DS, van Oosterhout AJ, Irene H Heijink, Simone M Brandenburg, Jacobien A Noordhoek, Dirk-Jan Slebos, Dirkje S Postma, Antoon J van Oosterhout

Abstract

Cigarette smoke, the major risk factor for COPD, is known to activate matrix metalloproteinases in airway epithelium. We investigated whether metalloproteinases, particularly A Disintegrin and Metalloproteinase (ADAM)17, contribute to increased pro-inflammatory epithelial responses with respect to the release of IL-8 and TGF-α, cytokines implicated in COPD pathogenesis.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 4%
Netherlands 1 4%
Unknown 25 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 26%
Researcher 5 19%
Other 3 11%
Student > Bachelor 3 11%
Student > Doctoral Student 1 4%
Other 3 11%
Unknown 5 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 30%
Biochemistry, Genetics and Molecular Biology 6 22%
Medicine and Dentistry 4 15%
Nursing and Health Professions 1 4%
Immunology and Microbiology 1 4%
Other 1 4%
Unknown 6 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 August 2012.
All research outputs
#3,335,891
of 4,703,378 outputs
Outputs from Respiratory Research
#573
of 676 outputs
Outputs of similar age
#49,829
of 75,916 outputs
Outputs of similar age from Respiratory Research
#11
of 15 outputs
Altmetric has tracked 4,703,378 research outputs across all sources so far. This one is in the 16th percentile – i.e., 16% of other outputs scored the same or lower than it.
So far Altmetric has tracked 676 research outputs from this source. They receive a mean Attention Score of 3.1. This one is in the 4th percentile – i.e., 4% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 75,916 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.