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Analysis of CpG methylation sites and CGI among human papillomavirus DNA genomes

Overview of attention for article published in BMC Genomics, November 2011
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Title
Analysis of CpG methylation sites and CGI among human papillomavirus DNA genomes
Published in
BMC Genomics, November 2011
DOI 10.1186/1471-2164-12-580
Pubmed ID
Authors

Silvia C Galván, Martha Martínez-Salazar, Víctor M Galván, Rocío Méndez, Gibran T Díaz-Contreras, Moisés Alvarado-Hermida, Rogelio Alcántara-Silva, Alejandro García-Carrancá

Abstract

The Human Papillomavirus (HPV) genome is divided into early and late coding sequences, including 8 open reading frames (ORFs) and a regulatory region (LCR). Viral gene expression may be regulated through epigenetic mechanisms, including cytosine methylation at CpG dinucleotides. We have analyzed the distribution of CpG sites and CpG islands/clusters (CGI) among 92 different HPV genomes grouped in function of their preferential tropism: cutaneous or mucosal. We calculated the proportion of CpG sites (PCS) for each ORF and calculated the expected CpG values for each viral type.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 3%
Colombia 1 3%
Unknown 32 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 24%
Student > Master 5 15%
Researcher 4 12%
Student > Doctoral Student 3 9%
Student > Postgraduate 3 9%
Other 5 15%
Unknown 6 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 44%
Biochemistry, Genetics and Molecular Biology 4 12%
Medicine and Dentistry 3 9%
Immunology and Microbiology 2 6%
Social Sciences 1 3%
Other 1 3%
Unknown 8 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 August 2012.
All research outputs
#10,995,802
of 12,373,620 outputs
Outputs from BMC Genomics
#6,423
of 7,296 outputs
Outputs of similar age
#104,584
of 121,876 outputs
Outputs of similar age from BMC Genomics
#80
of 97 outputs
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So far Altmetric has tracked 7,296 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 97 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.