Title |
Analysis of CpG methylation sites and CGI among human papillomavirus DNA genomes
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Published in |
BMC Genomics, November 2011
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DOI | 10.1186/1471-2164-12-580 |
Pubmed ID | |
Authors |
Silvia C Galván, Martha Martínez-Salazar, Víctor M Galván, Rocío Méndez, Gibran T Díaz-Contreras, Moisés Alvarado-Hermida, Rogelio Alcántara-Silva, Alejandro García-Carrancá |
Abstract |
The Human Papillomavirus (HPV) genome is divided into early and late coding sequences, including 8 open reading frames (ORFs) and a regulatory region (LCR). Viral gene expression may be regulated through epigenetic mechanisms, including cytosine methylation at CpG dinucleotides. We have analyzed the distribution of CpG sites and CpG islands/clusters (CGI) among 92 different HPV genomes grouped in function of their preferential tropism: cutaneous or mucosal. We calculated the proportion of CpG sites (PCS) for each ORF and calculated the expected CpG values for each viral type. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 3% |
Colombia | 1 | 3% |
Unknown | 31 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 24% |
Student > Master | 5 | 15% |
Researcher | 4 | 12% |
Student > Doctoral Student | 3 | 9% |
Student > Postgraduate | 3 | 9% |
Other | 6 | 18% |
Unknown | 4 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 15 | 45% |
Biochemistry, Genetics and Molecular Biology | 4 | 12% |
Medicine and Dentistry | 3 | 9% |
Immunology and Microbiology | 2 | 6% |
Social Sciences | 2 | 6% |
Other | 1 | 3% |
Unknown | 6 | 18% |