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Computational modeling of the bHLH domain of the transcription factor TWIST1 and R118C, S144R and K145E mutants

Overview of attention for article published in BMC Bioinformatics, July 2012
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (52nd percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

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2 tweeters

Citations

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19 Dimensions

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26 Mendeley
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Title
Computational modeling of the bHLH domain of the transcription factor TWIST1 and R118C, S144R and K145E mutants
Published in
BMC Bioinformatics, July 2012
DOI 10.1186/1471-2105-13-184
Pubmed ID
Authors

Amanda M Maia, João HM da Silva, André L Mencalha, Ernesto R Caffarena, Eliana Abdelhay

Abstract

Human TWIST1 is a highly conserved member of the regulatory basic helix-loop-helix (bHLH) transcription factors. TWIST1 forms homo- or heterodimers with E-box proteins, such as E2A (isoforms E12 and E47), MYOD and HAND2. Haploinsufficiency germ-line mutations of the twist1 gene in humans are the main cause of Saethre-Chotzen syndrome (SCS), which is characterized by limb abnormalities and premature fusion of cranial sutures. Because of the importance of TWIST1 in the regulation of embryonic development and its relationship with SCS, along with the lack of an experimentally solved 3D structure, we performed comparative modeling for the TWIST1 bHLH region arranged into wild-type homodimers and heterodimers with E47. In addition, three mutations that promote DNA binding failure (R118C, S144R and K145E) were studied on the TWIST1 monomer. We also explored the behavior of the mutant forms in aqueous solution using molecular dynamics (MD) simulations, focusing on the structural changes of the wild-type versus mutant dimers.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 4%
Unknown 25 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 31%
Student > Bachelor 4 15%
Researcher 4 15%
Student > Master 3 12%
Student > Postgraduate 2 8%
Other 1 4%
Unknown 4 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 38%
Biochemistry, Genetics and Molecular Biology 6 23%
Computer Science 2 8%
Immunology and Microbiology 1 4%
Psychology 1 4%
Other 1 4%
Unknown 5 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 August 2012.
All research outputs
#6,707,262
of 12,373,386 outputs
Outputs from BMC Bioinformatics
#2,504
of 4,576 outputs
Outputs of similar age
#56,484
of 122,025 outputs
Outputs of similar age from BMC Bioinformatics
#10
of 39 outputs
Altmetric has tracked 12,373,386 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,576 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 122,025 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.