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Sex-related differences in pain behaviors following three early life stress paradigms

Overview of attention for article published in Biology of Sex Differences, June 2016
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  • Above-average Attention Score compared to outputs of the same age (56th percentile)

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Sex-related differences in pain behaviors following three early life stress paradigms
Published in
Biology of Sex Differences, June 2016
DOI 10.1186/s13293-016-0082-x
Pubmed ID

Dawn K. Prusator, Beverley Greenwood-Van Meerveld


Early life stress (ELS) serves as a risk factor for the development of functional pain disorders such as irritable bowel syndrome (IBS) in adults. Although rodent models have been developed to mimic different forms of ELS experience, the use of predominantly male animals across various rodent strains has led to a paucity of information regarding sex-related differences in the persistent effects of ELS on pain behaviors in adulthood. We hypothesized that the context or nature of ELS experience may interact with sex differences to influence the development of chronic pain. We employed three rodent models mimicking different facets of early life adversity to investigate the effects of ELS on pain perception in adulthood. To eliminate strain differences, all experiments were carried out using Long Evans rats. As neonates, male and female rat pups were exposed to maternal separation (MS), limited nesting (LN), or odor attachment learning (OAL). In adulthood, visceral sensitivity and somatic sensitivity were assessed at ~postnatal day 90 via quantification of visceromotor responses to colorectal distension and von Frey probing, respectively. Following exposure to MS or LN, male rats developed visceral and somatic hypersensitivity compared to controls, whereas females subjected to the same paradigms were normosensitive. In the OAL model, females exposed to unpredictable ELS exhibited visceral but not somatic hypersensitivity. There were no observed differences in visceral or somatic sensitivity in male animals following OAL exposure. In summary, our data confirms that early adverse experiences in the form of MS, LN, and OAL contribute to the long-term development of heightened pain responsiveness in adulthood. Furthermore, this study indicates that sex-related vulnerability or resilience for the development of heightened pain perception is directly associated with the context or nature of the ELS experienced.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 2%
Unknown 61 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 18%
Student > Bachelor 10 16%
Student > Ph. D. Student 8 13%
Researcher 8 13%
Professor > Associate Professor 4 6%
Other 9 15%
Unknown 12 19%
Readers by discipline Count As %
Medicine and Dentistry 12 19%
Psychology 11 18%
Neuroscience 10 16%
Agricultural and Biological Sciences 6 10%
Nursing and Health Professions 3 5%
Other 6 10%
Unknown 14 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 June 2016.
All research outputs
of 7,896,890 outputs
Outputs from Biology of Sex Differences
of 142 outputs
Outputs of similar age
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Outputs of similar age from Biology of Sex Differences
of 7 outputs
Altmetric has tracked 7,896,890 research outputs across all sources so far. This one has received more attention than most of these and is in the 54th percentile.
So far Altmetric has tracked 142 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.7. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,984 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.