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Thrombospondin 1 in hypoxia-conditioned media blocks the growth of human microvascular endothelial cells and is increased in systemic sclerosis tissues

Overview of attention for article published in Fibrogenesis & Tissue Repair, June 2011
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Title
Thrombospondin 1 in hypoxia-conditioned media blocks the growth of human microvascular endothelial cells and is increased in systemic sclerosis tissues
Published in
Fibrogenesis & Tissue Repair, June 2011
DOI 10.1186/1755-1536-4-13
Pubmed ID
Authors

Luke Morgan-Rowe, Joanna Nikitorowicz, Xu Shiwen, Andrew Leask, Janice Tsui, David Abraham, Richard Stratton

Abstract

Systemic sclerosis (SSc) is a chronic inflammatory autoimmune disease characterised by vascular dysfunction and damage, excess collagen deposition and subsequent organ manifestations. Vasculopathy is an early feature of the disease which leads to a chronic hypoxic environment in the tissues. Paradoxically, there is a lack of angiogenesis. We hypothesised that this may in part be due to a nonphysiological, overriding upregulation in antiangiogenic factors produced by the hypoxic tissues. We considered thrombospondin 1 (TSP-1) as a candidate antiangiogenic factor.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 6%
Singapore 1 6%
Unknown 15 88%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 24%
Student > Doctoral Student 3 18%
Researcher 2 12%
Professor > Associate Professor 2 12%
Student > Master 1 6%
Other 2 12%
Unknown 3 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 35%
Medicine and Dentistry 4 24%
Biochemistry, Genetics and Molecular Biology 2 12%
Nursing and Health Professions 1 6%
Engineering 1 6%
Other 0 0%
Unknown 3 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 August 2012.
All research outputs
#20,163,398
of 22,673,450 outputs
Outputs from Fibrogenesis & Tissue Repair
#75
of 83 outputs
Outputs of similar age
#103,211
of 111,193 outputs
Outputs of similar age from Fibrogenesis & Tissue Repair
#2
of 3 outputs
Altmetric has tracked 22,673,450 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 83 research outputs from this source. They receive a mean Attention Score of 4.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 111,193 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.