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Potential of immunomodulatory agents as adjunct host-directed therapies for multidrug-resistant tuberculosis

Overview of attention for article published in BMC Medicine, June 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (55th percentile)

Mentioned by

twitter
6 tweeters

Citations

dimensions_citation
49 Dimensions

Readers on

mendeley
142 Mendeley
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Title
Potential of immunomodulatory agents as adjunct host-directed therapies for multidrug-resistant tuberculosis
Published in
BMC Medicine, June 2016
DOI 10.1186/s12916-016-0635-1
Pubmed ID
Authors

Alimuddin Zumla, Martin Rao, Ernest Dodoo, Markus Maeurer

Abstract

Treatment of multidrug-resistant tuberculosis (MDR-TB) is extremely challenging due to the virulence of the etiologic strains of Mycobacterium tuberculosis (M. tb), the aberrant host immune responses and the diminishing treatment options with TB drugs. New treatment regimens incorporating therapeutics targeting both M. tb and host factors are urgently needed to improve the clinical management outcomes of MDR-TB. Host-directed therapies (HDT) could avert destructive tuberculous lung pathology, facilitate eradication of M. tb, improve survival and prevent long-term functional disability. In this review we (1) discuss the use of HDT for cancer and other infections, drawing parallels and the precedent they set for MDR-TB treatment, (2) highlight preclinical studies of pharmacological agents commonly used in clinical practice which have HDT potential, and (3) outline developments in cellular therapy to promote clinically beneficial immunomodulation to improve treatment outcomes in patients with pulmonary MDR-TB. The use of HDTs as adjuncts to MDR-TB therapy requires urgent evaluation.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 142 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 <1%
Canada 1 <1%
Unknown 140 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 29 20%
Student > Ph. D. Student 24 17%
Student > Bachelor 20 14%
Researcher 13 9%
Student > Postgraduate 10 7%
Other 27 19%
Unknown 19 13%
Readers by discipline Count As %
Medicine and Dentistry 41 29%
Immunology and Microbiology 22 15%
Biochemistry, Genetics and Molecular Biology 15 11%
Pharmacology, Toxicology and Pharmaceutical Science 9 6%
Agricultural and Biological Sciences 8 6%
Other 15 11%
Unknown 32 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 December 2016.
All research outputs
#8,765,632
of 15,916,297 outputs
Outputs from BMC Medicine
#2,081
of 2,485 outputs
Outputs of similar age
#114,932
of 268,020 outputs
Outputs of similar age from BMC Medicine
#1
of 2 outputs
Altmetric has tracked 15,916,297 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,485 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 36.9. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,020 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them