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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Potential of immunomodulatory agents as adjunct host-directed therapies for multidrug-resistant tuberculosis
|
|---|---|
| Published in |
BMC Medicine, June 2016
|
| DOI | 10.1186/s12916-016-0635-1 |
| Pubmed ID | |
| Authors |
Alimuddin Zumla, Martin Rao, Ernest Dodoo, Markus Maeurer |
| Abstract |
Treatment of multidrug-resistant tuberculosis (MDR-TB) is extremely challenging due to the virulence of the etiologic strains of Mycobacterium tuberculosis (M. tb), the aberrant host immune responses and the diminishing treatment options with TB drugs. New treatment regimens incorporating therapeutics targeting both M. tb and host factors are urgently needed to improve the clinical management outcomes of MDR-TB. Host-directed therapies (HDT) could avert destructive tuberculous lung pathology, facilitate eradication of M. tb, improve survival and prevent long-term functional disability. In this review we (1) discuss the use of HDT for cancer and other infections, drawing parallels and the precedent they set for MDR-TB treatment, (2) highlight preclinical studies of pharmacological agents commonly used in clinical practice which have HDT potential, and (3) outline developments in cellular therapy to promote clinically beneficial immunomodulation to improve treatment outcomes in patients with pulmonary MDR-TB. The use of HDTs as adjuncts to MDR-TB therapy requires urgent evaluation. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 50% |
| Italy | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 179 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 177 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 30 | 17% |
| Student > Ph. D. Student | 25 | 14% |
| Student > Bachelor | 23 | 13% |
| Researcher | 16 | 9% |
| Other | 12 | 7% |
| Other | 31 | 17% |
| Unknown | 42 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 44 | 25% |
| Immunology and Microbiology | 22 | 12% |
| Biochemistry, Genetics and Molecular Biology | 16 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 11 | 6% |
| Agricultural and Biological Sciences | 9 | 5% |
| Other | 22 | 12% |
| Unknown | 55 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 December 2016.
All research outputs
#14,718,998
of 23,577,654 outputs
Outputs from BMC Medicine
#3,033
of 3,569 outputs
Outputs of similar age
#203,586
of 354,464 outputs
Outputs of similar age from BMC Medicine
#40
of 42 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,569 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 44.5. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 354,464 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.