Title |
Evaluation of the effects of botulinum toxin A injections when used to improve ease of care and comfort in children with cerebral palsy whom are non-ambulant: a double blind randomized controlled trial
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Published in |
BMC Pediatrics, August 2012
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DOI | 10.1186/1471-2431-12-120 |
Pubmed ID | |
Authors |
Megan Thorley, Samantha Donaghey, Priya Edwards, Lisa Copeland, Megan Kentish, Kim McLennan, Jayne Lindsley, Laura Gascoigne-Pees, Leanne Sakzewski, Roslyn N Boyd |
Abstract |
Children with cerebral palsy (CP) whom are non-ambulant are at risk of reduced quality of life and poor health status. Severe spasticity leads to discomfort and pain. Carer burden for families is significant. This study aims to determine whether intramuscular injections of botulinum toxin A (BoNT-A) combined with a regime of standard therapy has a positive effect on care and comfort for children with CP whom are non-ambulant (GMFCS IV/V), compared with standard therapy alone (cycle I), and whether repeated injections with the same regime of adjunctive therapy results in greater benefits compared with a single injecting episode (cycle II). The regime of therapy will include serial casting, splinting and/or provision of orthoses, as indicated, combined with four sessions of goal directed occupational therapy or physiotherapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Italy | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Australia | 2 | <1% |
South Africa | 1 | <1% |
United Kingdom | 1 | <1% |
Canada | 1 | <1% |
Spain | 1 | <1% |
Unknown | 198 | 97% |
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Student > Master | 32 | 16% |
Student > Bachelor | 28 | 14% |
Researcher | 19 | 9% |
Student > Doctoral Student | 18 | 9% |
Student > Ph. D. Student | 18 | 9% |
Other | 39 | 19% |
Unknown | 50 | 25% |
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Nursing and Health Professions | 37 | 18% |
Psychology | 10 | 5% |
Sports and Recreations | 8 | 4% |
Social Sciences | 8 | 4% |
Other | 27 | 13% |
Unknown | 60 | 29% |