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The failure of protein cancer biomarkers to reach the clinic: why, and what can be done to address the problem?

Overview of attention for article published in BMC Medicine, August 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (55th percentile)

Mentioned by

blogs
1 blog
twitter
7 tweeters

Citations

dimensions_citation
129 Dimensions

Readers on

mendeley
183 Mendeley
citeulike
2 CiteULike
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Title
The failure of protein cancer biomarkers to reach the clinic: why, and what can be done to address the problem?
Published in
BMC Medicine, August 2012
DOI 10.1186/1741-7015-10-87
Pubmed ID
Authors

Eleftherios P Diamandis

Abstract

There is a plethora of published cancer biomarkers but the reality is that very few, if any, new circulating cancer biomarkers have entered the clinic in the last 30 years. I here try to explain this apparent oxymoron by classifying circulating cancer biomarkers into three categories: fraudulent reports (rare); true discoveries of biomarkers, that then fail to meet the demands of the clinic; and false discoveries, which represent artifactual biomarkers. I further provide examples of combinations of some known cancer biomarkers that can perform well in niche clinical applications, despite individually being not useful.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 183 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 <1%
France 1 <1%
Taiwan 1 <1%
Canada 1 <1%
Unknown 179 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 42 23%
Researcher 34 19%
Student > Bachelor 22 12%
Student > Master 20 11%
Other 12 7%
Other 34 19%
Unknown 19 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 49 27%
Biochemistry, Genetics and Molecular Biology 35 19%
Medicine and Dentistry 35 19%
Chemistry 15 8%
Computer Science 5 3%
Other 20 11%
Unknown 24 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 October 2013.
All research outputs
#1,144,047
of 12,517,134 outputs
Outputs from BMC Medicine
#920
of 2,010 outputs
Outputs of similar age
#11,236
of 121,478 outputs
Outputs of similar age from BMC Medicine
#8
of 18 outputs
Altmetric has tracked 12,517,134 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,010 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.9. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 121,478 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.