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Pro: Alzheimer's disease and circadian dysfunction: chicken or egg?

Overview of attention for article published in Alzheimer's Research & Therapy, August 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

Mentioned by

blogs
1 blog
twitter
2 X users

Citations

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25 Dimensions

Readers on

mendeley
64 Mendeley
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Title
Pro: Alzheimer's disease and circadian dysfunction: chicken or egg?
Published in
Alzheimer's Research & Therapy, August 2012
DOI 10.1186/alzrt128
Pubmed ID
Authors

Tracy A Bedrosian, Randy J Nelson

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease that accounts for most cases of dementia. Besides progressive cognitive decline, circadian dysfunction is a prominent feature of AD. Circadian disruption is traditionally regarded as a downstream symptom of AD, but recent evidence suggests that circadian dysregulation may act to exacerbate AD pathology. A reciprocal link among sleep, circadian rhythms, and amyloid deposition has long been suspected, and data from both human and animal studies support this hypothesis. The sleep-wake cycle regulates amyloid-beta (Aβ) levels in both mice and humans. Sleep deprivation increases Aβ levels in mice, and sleep apnea and insomnia may be related to AD in humans. Furthermore, melatonin, the principal hormonal output of the circadian system, is dysregulated in AD, and this may be important because melatonin is protective in cells exposed to toxic Aβ. Initial evidence supports a reciprocal link among sleep, circadian rhythmicity, and AD. More investigation is necessary to replicate these studies and determine the extent to which the circadian system contributes to the pathogenesis of AD.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
United States 1 2%
Unknown 62 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 11 17%
Student > Ph. D. Student 9 14%
Researcher 7 11%
Student > Master 7 11%
Student > Doctoral Student 5 8%
Other 10 16%
Unknown 15 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 25%
Neuroscience 10 16%
Medicine and Dentistry 10 16%
Psychology 4 6%
Biochemistry, Genetics and Molecular Biology 2 3%
Other 4 6%
Unknown 18 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 August 2012.
All research outputs
#3,778,616
of 25,373,627 outputs
Outputs from Alzheimer's Research & Therapy
#1,031
of 1,464 outputs
Outputs of similar age
#25,876
of 185,774 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#6
of 16 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,464 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.6. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 185,774 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.