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A novel Rho-dependent pathway that drives interaction of fascin-1 with p-Lin-11/Isl-1/Mec-3 kinase (LIMK) 1/2 to promote fascin-1/actin binding and filopodia stability

Overview of attention for article published in BMC Biology, August 2012
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Title
A novel Rho-dependent pathway that drives interaction of fascin-1 with p-Lin-11/Isl-1/Mec-3 kinase (LIMK) 1/2 to promote fascin-1/actin binding and filopodia stability
Published in
BMC Biology, August 2012
DOI 10.1186/1741-7007-10-72
Pubmed ID
Authors

Asier Jayo, Maddy Parsons, Josephine C Adams

Abstract

Fascin-1 is an actin crosslinking protein that is important for the assembly of cell protrusions in neurons, skeletal and smooth muscle, fibroblasts, and dendritic cells. Although absent from most normal adult epithelia, fascin-1 is upregulated in many human carcinomas, and is associated with poor prognosis because of its promotion of carcinoma cell migration, invasion, and metastasis. Rac and Cdc42 small guanine triphosphatases have been identified as upstream regulators of the association of fascin-1 with actin, but the possible role of Rho has remained obscure. Additionally, experiments have been hampered by the inability to measure the fascin-1/actin interaction directly in intact cells. We investigated the hypothesis that fascin-1 is a functional target of Rho in normal and carcinoma cells, using experimental approaches that included a novel fluorescence resonance energy transfer (FRET)/fluorescence lifetime imaging (FLIM) method to measure the interaction of fascin-1 with actin.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Singapore 1 2%
Korea, Republic of 1 2%
Japan 1 2%
United States 1 2%
Unknown 56 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 26%
Researcher 12 20%
Student > Master 9 15%
Student > Doctoral Student 5 8%
Student > Bachelor 3 5%
Other 6 10%
Unknown 10 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 21 34%
Biochemistry, Genetics and Molecular Biology 14 23%
Medicine and Dentistry 6 10%
Immunology and Microbiology 3 5%
Unspecified 1 2%
Other 4 7%
Unknown 12 20%