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An autoradiographic evaluation of AV-1451 Tau PET in dementia

Overview of attention for article published in Acta Neuropathologica Communications, June 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#30 of 1,241)
  • High Attention Score compared to outputs of the same age (96th percentile)

Mentioned by

news
8 news outlets
blogs
1 blog

Citations

dimensions_citation
333 Dimensions

Readers on

mendeley
187 Mendeley
citeulike
1 CiteULike
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Title
An autoradiographic evaluation of AV-1451 Tau PET in dementia
Published in
Acta Neuropathologica Communications, June 2016
DOI 10.1186/s40478-016-0315-6
Pubmed ID
Authors

Val J. Lowe, Geoffry Curran, Ping Fang, Amanda M. Liesinger, Keith A. Josephs, Joseph E. Parisi, Kejal Kantarci, Bradley F. Boeve, Mukesh K. Pandey, Tyler Bruinsma, David S. Knopman, David T. Jones, Leonard Petrucelli, Casey N. Cook, Neill R. Graff-Radford, Dennis W. Dickson, Ronald C. Petersen, Clifford R. Jack, Melissa E. Murray

Abstract

It is essential to determine the specificity of AV-1451 PET for tau in brain imaging by using pathological comparisons. We performed autoradiography in autopsy-confirmed Alzheimer disease and other neurodegenerative disorders to evaluate the specificity of AV-1451 binding for tau aggregates. Tissue samples were selected that had a variety of dementia-related neuropathologies including Alzheimer disease, primary age-related tauopathy, tangle predominant dementia, non-Alzheimer disease tauopathies, frontotemporal dementia, parkinsonism, Lewy body disease and multiple system atrophy (n = 38). Brain tissue sections were stained for tau, TAR DNA-binding protein-43, and α-synuclein and compared to AV-1451 autoradiography on adjacent sections. AV-1451 preferentially localized to neurofibrillary tangles, with less binding to areas enriched in neuritic pathology and less mature tau. The strength of AV-1451 binding with respect to tau isoforms in various neurodegenerative disorders was: 3R + 4R tau (e.g., AD) > 3R tau (e.g., Pick disease) or 4R tau. Only minimal binding of AV-1451 to TAR DNA-binding protein-43 positive regions was detected. No binding of AV-1451 to α-synuclein was detected. "Off-target" binding was seen in vessels, iron-associated regions, substantia nigra, calcifications in the choroid plexus, and leptomeningeal melanin. Reduced AV-1451 binding in neuritic pathology compared to neurofibrillary tangles suggests that the maturity of tau pathology may affect AV-1451 binding and suggests complexity in AV-1451 binding. Poor association of AV-1451 with tauopathies that have preferential accumulation of either 4R tau or 3R tau suggests limited clinical utility in detecting these pathologies. In contrast, for disorders associated with 3R + 4R tau, such as Alzheimer disease, AV-1451 binds tau avidly but does not completely reflect the early stage tau progression suggested by Braak neurofibrillary tangle staging. AV-1451 binding to TAR DNA-binding protein-43 or TAR DNA-binding protein-43 positive regions can be weakly positive. Clinical use of AV-1451 will require a familiarity with distinct types of "off-target" binding.

Mendeley readers

The data shown below were compiled from readership statistics for 187 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 2%
Unknown 184 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 46 25%
Student > Ph. D. Student 39 21%
Student > Master 18 10%
Other 15 8%
Student > Bachelor 12 6%
Other 31 17%
Unknown 26 14%
Readers by discipline Count As %
Neuroscience 56 30%
Medicine and Dentistry 26 14%
Agricultural and Biological Sciences 16 9%
Psychology 11 6%
Engineering 8 4%
Other 23 12%
Unknown 47 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 64. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2021.
All research outputs
#497,387
of 20,942,040 outputs
Outputs from Acta Neuropathologica Communications
#30
of 1,241 outputs
Outputs of similar age
#10,659
of 276,963 outputs
Outputs of similar age from Acta Neuropathologica Communications
#1
of 1 outputs
Altmetric has tracked 20,942,040 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,241 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.5. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,963 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them