Title |
Brachial Artery Flow-mediated Dilation Following Exercise with Augmented Oscillatory and Retrograde Shear Rate
|
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Published in |
Cardiovascular Ultrasound, August 2012
|
DOI | 10.1186/1476-7120-10-34 |
Pubmed ID | |
Authors |
Blair D Johnson, Kieren J Mather, Sean C Newcomer, Timothy D Mickleborough, Janet P Wallace |
Abstract |
Acute doses of elevated retrograde shear rate (SR) appear to be detrimental to endothelial function in resting humans. However, retrograde shear increases during moderate intensity exercise which also enhances post-exercise endothelial function. Since SR patterns differ with the modality of exercise, it is important to determine if augmented retrograde SR during exercise influences post-exercise endothelial function. This study tested the hypothesis that (1) increased doses of retrograde SR in the brachial artery during lower body supine cycle ergometer exercise would attenuate post-exercise flow-mediated dilation (FMD) in a dose-dependent manner, and (2) antioxidant vitamin C supplementation would prevent the attenuated post-exercise FMD response. |
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