Title |
How important is gametocyte clearance after malaria therapy?
|
---|---|
Published in |
BMC Medicine, June 2016
|
DOI | 10.1186/s12916-016-0641-3 |
Pubmed ID | |
Authors |
Harin A. Karunajeewa, Ivo Mueller |
Abstract |
There has been increasing interest in the role of malaria drugs in preventing malaria transmission from humans to mosquitoes, which would help augment malaria control and elimination strategies. Nevertheless, only one stage in the malaria parasite life cycle, the gametocyte, is infectious to mosquitoes. The Worldwide Antimalarial Resistance Network (WWARN) have analyzed data from 48,840 patients from 141 clinical trials in order to define the nature and determinants of gametocyte clearance following artemisinin combination treatment (ACT) for symptomatic malaria infections. However, the presence of gametocytes does not always predict their infectivity, meaning that the microscopy-based methods used by the WWARN investigators represent an imperfect surrogate marker of transmissibility. Their findings, that some ACTs clear gametocytes faster than others, should be interpreted in light of these limitations and important gaps in our understanding of the biology and epidemiology of malaria transmission.Please see related article: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-016-0621-7. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Kenya | 2 | 17% |
United Kingdom | 2 | 17% |
United States | 1 | 8% |
Spain | 1 | 8% |
Unknown | 6 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 50% |
Scientists | 3 | 25% |
Practitioners (doctors, other healthcare professionals) | 2 | 17% |
Science communicators (journalists, bloggers, editors) | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 64 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 14 | 22% |
Student > Ph. D. Student | 8 | 13% |
Student > Bachelor | 6 | 9% |
Student > Master | 5 | 8% |
Student > Doctoral Student | 3 | 5% |
Other | 10 | 16% |
Unknown | 18 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 14 | 22% |
Medicine and Dentistry | 8 | 13% |
Immunology and Microbiology | 6 | 9% |
Agricultural and Biological Sciences | 5 | 8% |
Chemistry | 3 | 5% |
Other | 8 | 13% |
Unknown | 20 | 31% |