Title |
Developing core outcome sets for clinical trials: issues to consider
|
---|---|
Published in |
Trials, August 2012
|
DOI | 10.1186/1745-6215-13-132 |
Pubmed ID | |
Authors |
Paula R Williamson, Douglas G Altman, Jane M Blazeby, Mike Clarke, Declan Devane, Elizabeth Gargon, Peter Tugwell |
Abstract |
The selection of appropriate outcomes or domains is crucial when designing clinical trials in order to compare directly the effects of different interventions in ways that minimize bias. If the findings are to influence policy and practice then the chosen outcomes need to be relevant and important to key stakeholders including patients and the public, health care professionals and others making decisions about health care. There is a growing recognition that insufficient attention has been paid to the outcomes measured in clinical trials. These issues could be addressed through the development and use of an agreed standardized collection of outcomes, known as a core outcome set, which should be measured and reported, as a minimum, in all trials for a specific clinical area. Accumulating work in this area has identified the need for general guidance on the development of core outcome sets. Key issues to consider in the development of a core outcome set include its scope, the stakeholder groups to involve, choice of consensus method and the achievement of a consensus. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 15 | 37% |
United States | 4 | 10% |
Canada | 3 | 7% |
Australia | 1 | 2% |
Portugal | 1 | 2% |
Unknown | 17 | 41% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 28 | 68% |
Scientists | 7 | 17% |
Practitioners (doctors, other healthcare professionals) | 6 | 15% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 10 | 2% |
Germany | 1 | <1% |
Korea, Republic of | 1 | <1% |
Italy | 1 | <1% |
Portugal | 1 | <1% |
Australia | 1 | <1% |
Canada | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Other | 0 | 0% |
Unknown | 501 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 97 | 19% |
Researcher | 85 | 16% |
Student > Master | 50 | 10% |
Other | 37 | 7% |
Student > Bachelor | 29 | 6% |
Other | 115 | 22% |
Unknown | 106 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 204 | 39% |
Nursing and Health Professions | 46 | 9% |
Psychology | 20 | 4% |
Social Sciences | 18 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 14 | 3% |
Other | 66 | 13% |
Unknown | 151 | 29% |