Title |
The role of Transposable Elements in shaping the combinatorial interaction of Transcription Factors
|
---|---|
Published in |
BMC Genomics, August 2012
|
DOI | 10.1186/1471-2164-13-400 |
Pubmed ID | |
Authors |
Alessandro Testori, Livia Caizzi, Santina Cutrupi, Olivier Friard, Michele De Bortoli, Davide Cora', Michele Caselle |
Abstract |
In the last few years several studies have shown that Transposable Elements (TEs) in the human genome are significantly associated with Transcription Factor Binding Sites (TFBSs) and that in several cases their expansion within the genome led to a substantial rewiring of the regulatory network. Another important feature of the regulatory network which has been thoroughly studied is the combinatorial organization of transcriptional regulation. In this paper we combine these two observations and suggest that TEs, besides rewiring the network, also played a central role in the evolution of particular patterns of combinatorial gene regulation. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 25% |
Spain | 1 | 25% |
Australia | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Scientists | 3 | 75% |
Members of the public | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 2 | 2% |
Brazil | 2 | 2% |
United States | 2 | 2% |
United Kingdom | 2 | 2% |
Netherlands | 1 | 1% |
Spain | 1 | 1% |
Canada | 1 | 1% |
Unknown | 75 | 87% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 17 | 20% |
Student > Master | 17 | 20% |
Researcher | 16 | 19% |
Professor | 6 | 7% |
Student > Doctoral Student | 5 | 6% |
Other | 12 | 14% |
Unknown | 13 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 41 | 48% |
Biochemistry, Genetics and Molecular Biology | 15 | 17% |
Business, Management and Accounting | 2 | 2% |
Neuroscience | 2 | 2% |
Medicine and Dentistry | 2 | 2% |
Other | 6 | 7% |
Unknown | 18 | 21% |