Title |
Failure of delayed nonsynaptic neuronal plasticity underlies age-associated long-term associative memory impairment
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Published in |
BMC Neuroscience, August 2012
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DOI | 10.1186/1471-2202-13-103 |
Pubmed ID | |
Authors |
Shawn N Watson, Tara E Risling, Petra M Hermann, Willem C Wildering |
Abstract |
Cognitive impairment associated with subtle changes in neuron and neuronal network function rather than widespread neuron death is a feature of the normal aging process in humans and animals. Despite its broad evolutionary conservation, the etiology of this aging process is not well understood. However, recent evidence suggests the existence of a link between oxidative stress in the form of progressive membrane lipid peroxidation, declining neuronal electrical excitability and functional decline of the normal aging brain. The current study applies a combination of behavioural and electrophysiological techniques and pharmacological interventions to explore this hypothesis in a gastropod model (Lymnaea stagnalis feeding system) that allows pinpointing the molecular and neurobiological foundations of age-associated long-term memory (LTM) failure at the level of individual identified neurons and synapses. |
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Mexico | 1 | 25% |
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United States | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
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Mendeley readers
Geographical breakdown
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Demographic breakdown
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Student > Bachelor | 12 | 16% |
Student > Ph. D. Student | 9 | 12% |
Student > Postgraduate | 5 | 7% |
Student > Doctoral Student | 4 | 5% |
Other | 14 | 19% |
Unknown | 15 | 20% |
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Biochemistry, Genetics and Molecular Biology | 4 | 5% |
Other | 6 | 8% |
Unknown | 15 | 20% |