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Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies

Overview of attention for article published in Genome Medicine, June 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (82nd percentile)

Mentioned by

news
8 news outlets
blogs
2 blogs
twitter
35 X users
facebook
1 Facebook page
wikipedia
5 Wikipedia pages
video
1 YouTube creator

Citations

dimensions_citation
475 Dimensions

Readers on

mendeley
1032 Mendeley
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Title
Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies
Published in
Genome Medicine, June 2016
DOI 10.1186/s13073-016-0324-x
Pubmed ID
Authors

Mohammad A. Jafri, Shakeel A. Ansari, Mohammed H. Alqahtani, Jerry W. Shay

Abstract

Telomeres maintain genomic integrity in normal cells, and their progressive shortening during successive cell divisions induces chromosomal instability. In the large majority of cancer cells, telomere length is maintained by telomerase. Thus, telomere length and telomerase activity are crucial for cancer initiation and the survival of tumors. Several pathways that regulate telomere length have been identified, and genome-scale studies have helped in mapping genes that are involved in telomere length control. Additionally, genomic screening for recurrent human telomerase gene hTERT promoter mutations and mutations in genes involved in the alternative lengthening of telomeres pathway, such as ATRX and DAXX, has elucidated how these genomic changes contribute to the activation of telomere maintenance mechanisms in cancer cells. Attempts have also been made to develop telomere length- and telomerase-based diagnostic tools and anticancer therapeutics. Recent efforts have revealed key aspects of telomerase assembly, intracellular trafficking and recruitment to telomeres for completing DNA synthesis, which may provide novel targets for the development of anticancer agents. Here, we summarize telomere organization and function and its role in oncogenesis. We also highlight genomic mutations that lead to reactivation of telomerase, and mechanisms of telomerase reconstitution and trafficking that shed light on its function in cancer initiation and tumor development. Additionally, recent advances in the clinical development of telomerase inhibitors, as well as potential novel targets, will be summarized.

X Demographics

X Demographics

The data shown below were collected from the profiles of 35 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 1,032 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 <1%
United States 1 <1%
India 1 <1%
Portugal 1 <1%
Unknown 1028 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 231 22%
Student > Master 153 15%
Student > Ph. D. Student 145 14%
Researcher 64 6%
Student > Doctoral Student 41 4%
Other 90 9%
Unknown 308 30%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 353 34%
Agricultural and Biological Sciences 84 8%
Medicine and Dentistry 72 7%
Chemistry 45 4%
Pharmacology, Toxicology and Pharmaceutical Science 33 3%
Other 96 9%
Unknown 349 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 95. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 January 2024.
All research outputs
#437,242
of 25,010,497 outputs
Outputs from Genome Medicine
#74
of 1,544 outputs
Outputs of similar age
#8,906
of 361,945 outputs
Outputs of similar age from Genome Medicine
#5
of 23 outputs
Altmetric has tracked 25,010,497 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,544 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.1. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 361,945 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.