Title |
Detecting transcription of ribosomal protein pseudogenes in diverse human tissues from RNA-seq data
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Published in |
BMC Genomics, August 2012
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DOI | 10.1186/1471-2164-13-412 |
Pubmed ID | |
Authors |
Peter Tonner, Vinodh Srinivasasainagendra, Shaojie Zhang, Degui Zhi |
Abstract |
Ribosomal proteins (RPs) have about 2000 pseudogenes in the human genome. While anecdotal reports for RP pseudogene transcription exists, it is unclear to what extent these pseudogenes are transcribed. The RP pseudogene transcription is difficult to identify in microarrays due to potential cross-hybridization between transcripts from the parent genes and pseudogenes. Recently, transcriptome sequencing (RNA-seq) provides an opportunity to ascertain the transcription of pseudogenes. A challenge for pseudogene expression discovery in RNA-seq data lies in the difficulty to uniquely identify reads mapped to pseudogene regions, which are typically also similar to the parent genes. |
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