↓ Skip to main content

The role of the purinergic P2X7 receptor in inflammation

Overview of attention for article published in Journal of Inflammation, March 2007
Altmetric Badge

Mentioned by

facebook
1 Facebook page

Citations

dimensions_citation
207 Dimensions

Readers on

mendeley
164 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
The role of the purinergic P2X7 receptor in inflammation
Published in
Journal of Inflammation, March 2007
DOI 10.1186/1476-9255-4-5
Pubmed ID
Authors

Martin F Lister, John Sharkey, Deborah A Sawatzky, Joseph P Hodgkiss, Donald J Davidson, Adriano G Rossi, Keith Finlayson

Abstract

The inflammatory process, orchestrated against a variety of injurious stimuli, is composed of three inter-related phases; initiation, propagation and resolution. Understanding the interplay between these three phases and harnessing the beneficial properties of inflammation whilst preventing its damaging effects, will undoubtedly lead to the advent of much needed therapies, particularly in chronic disease states. The P2X7 receptor (P2X7R) is increasingly recognised as an important cell surface regulator of several key inflammatory molecules including IL-1beta, IL-18, TNF-alpha and IL-6. Moreover, as P2X7R-dependent cytokine production is driven by activating the inflammasome, antagonists of this receptor are likely to have therapeutic potential as novel anti-inflammatory therapies. The function of the P2X7R in inflammation, immunity and its potential role in disease will be reviewed and discussed.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 164 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 2 1%
Colombia 1 <1%
United Kingdom 1 <1%
Brazil 1 <1%
Canada 1 <1%
United States 1 <1%
Unknown 157 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 40 24%
Researcher 21 13%
Student > Master 21 13%
Student > Bachelor 19 12%
Student > Doctoral Student 8 5%
Other 28 17%
Unknown 27 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 54 33%
Medicine and Dentistry 20 12%
Biochemistry, Genetics and Molecular Biology 14 9%
Immunology and Microbiology 10 6%
Neuroscience 9 5%
Other 21 13%
Unknown 36 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2012.
All research outputs
#22,759,452
of 25,374,647 outputs
Outputs from Journal of Inflammation
#393
of 425 outputs
Outputs of similar age
#87,907
of 90,726 outputs
Outputs of similar age from Journal of Inflammation
#3
of 3 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 425 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 90,726 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.