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Carcinosarcoma of the breast: two case reports and review of the literature

Overview of attention for article published in Cases Journal, January 2009
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Title
Carcinosarcoma of the breast: two case reports and review of the literature
Published in
Cases Journal, January 2009
DOI 10.1186/1757-1626-2-15
Pubmed ID
Authors

Kristi M Esses, Ramona M Hagmaier, Susan A Blanchard, John J Lazarchick, Adam I Riker

Abstract

Carcinosarcoma of the breast, often referred to as metaplastic carcinoma of the breast, is a rare malignancy with two distinct cell lines described as a breast carcinoma of ductal type with a sarcoma-like component. Clinically, carcinosarcoma of the breast is an aggressive breast cancer. The prognosis for carcinosarcoma of the breast is less favorable compared to more common types of breast cancer such as infiltrating ductal or lobular carcinoma. Currently, the evaluation of breast carcinoma includes hormone receptor analysis of the tumor tissue, with those positive for estrogen or progesterone responding better to both hormonal and chemotherapy.Trastuzumab (Herceptin(R)) is available as an adjunct treatment for tumors which over-express the HER2/neu gene. Typically, metaplastic carcinomas of the breast do not express the estrogen or progesterone receptors and do not over-express the HER2/neu oncogene. As a result of this "triple negative" phenotype, such tumors tend to be more aggressive and are unlikely to respond to targeted therapy with Herceptin. The epidermal growth factor receptor HER-1/EGFR protein is expressed in the majority of metaplastic carcinomas and thus may serve as a potential therapeutic target for EGFR inhibitors such as gefitinib and cetuximab. The two cases we describe exemplify the aggressive nature of carcinosarcoma of the breast and support the findings that this tumor type does not express the common receptors found in other breast carcinomas. These case reports also emphasize the need for investigating the role for blockade of the HER-1/EGFR receptor with targeted therapies when found to be over-expressed in the primary tumor.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 6%
Canada 1 6%
Unknown 15 88%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 24%
Student > Ph. D. Student 2 12%
Student > Doctoral Student 2 12%
Student > Postgraduate 2 12%
Student > Master 2 12%
Other 5 29%
Readers by discipline Count As %
Medicine and Dentistry 9 53%
Veterinary Science and Veterinary Medicine 2 12%
Pharmacology, Toxicology and Pharmaceutical Science 1 6%
Unspecified 1 6%
Agricultural and Biological Sciences 1 6%
Other 1 6%
Unknown 2 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 July 2012.
All research outputs
#16,633,831
of 18,804,592 outputs
Outputs from Cases Journal
#192
of 225 outputs
Outputs of similar age
#124,438
of 142,012 outputs
Outputs of similar age from Cases Journal
#1
of 1 outputs
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So far Altmetric has tracked 225 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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