Title |
Ingredients of Huangqi decoction slow biliary fibrosis progression by inhibiting the activation of the transforming growth factor-beta signaling pathway
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Published in |
BMC Complementary Medicine and Therapies, April 2012
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DOI | 10.1186/1472-6882-12-33 |
Pubmed ID | |
Authors |
Jin-Xing Du, Ming-Yu Sun, Guang-Li Du, Feng-Hua Li, Cheng Liu, Yong-Ping Mu, Gao-Feng Chen, Ai-Hua Long, Yan-Qin Bian, Jia Liu, Cheng-Hai Liu, Yi-Yang Hu, Lie-Ming Xu, Ping Liu |
Abstract |
Huangqi decoction was first described in Prescriptions of the Bureau of Taiping People's Welfare Pharmacy in Song Dynasty (AD 1078), and it is an effective recipe that is usually used to treat consumptive disease, anorexia, and chronic liver diseases. Transforming growth factor beta 1 (TGFβ1) plays a key role in the progression of liver fibrosis, and Huangqi decoction and its ingredients (IHQD) markedly ameliorated hepatic fibrotic lesions induced by ligation of the common bile duct (BDL). However, the mechanism of IHQD on hepatic fibrotic lesions is not yet clear. The purpose of the present study is to elucidate the roles of TGFβ1 activation, Smad-signaling pathway, and extracellular signal-regulated kinase (ERK) in the pathogenesis of biliary fibrosis progression and the antifibrotic mechanism of IHQD. |
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