Title |
Experimental chronic hepatitis B infection of neonatal tree shrews (Tupaia belangeri chinensis): A model to study molecular causes for susceptibility and disease progression to chronic hepatitis in humans
|
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Published in |
Virology Journal, August 2012
|
DOI | 10.1186/1743-422x-9-170 |
Pubmed ID | |
Authors |
Qi Wang, Paul Schwarzenberger, Fang Yang, Jingjing Zhang, Jianjia Su, Chun Yang, Ji Cao, Chao Ou, Liang Liang, Junlin Shi, Fang Yang, Duoping Wang, Jia Wang, Xiaojuan Wang, Ping Ruan, Yuan Li |
Abstract |
Hepatitis B virus (HBV) infection continues to be an escalating global health problem. Feasible and effective animal models for HBV infection are the prerequisite for developing novel therapies for this disease. The tree shrew (Tupaia) is a small animal species evolutionary closely related to humans, and thus is permissive to certain human viral pathogens. Whether tree shrews could be chronically infected with HBV in vivo has been controversial for decades. Most published research has been reported on adult tree shrews, and only small numbers of HBV infected newborn tree shrews had been observed over short time periods. We investigated susceptibility of newborn tree shrews to experimental HBV infection as well as viral clearance over a protracted time period. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
Colombia | 1 | 33% |
United Kingdom | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 5% |
Unknown | 18 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 21% |
Student > Ph. D. Student | 4 | 21% |
Other | 3 | 16% |
Student > Master | 2 | 11% |
Professor | 1 | 5% |
Other | 1 | 5% |
Unknown | 4 | 21% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 4 | 21% |
Computer Science | 1 | 5% |
Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Immunology and Microbiology | 1 | 5% |
Other | 1 | 5% |
Unknown | 5 | 26% |