Title |
Gluten encephalopathy with psychiatric onset: case report
|
---|---|
Published in |
Clinical Practice and Epidemiology in Mental Health, June 2009
|
DOI | 10.1186/1745-0179-5-16 |
Pubmed ID | |
Authors |
Nicola Poloni, Simone Vender, Emilio Bolla, Paola Bortolaso, Chiara Costantini, Camilla Callegari |
Abstract |
Many cases of coeliac disease, a gastrointestinal autoimmune disorder caused by sensitivity to gluten, can remain in a subclinical stage or undiagnosed. In a significant proportion of cases (10-15%) gluten intolerance can be associated with central or peripheral nervous system and psychiatric disorders.A 38-year-old man was admitted as to our department an inpatient for worsening anxiety symptoms and behavioural alterations. After the addition of second generation antipsychotic to the therapeutic regimen, the patient presented neuromotor impairment with high fever, sopor, leukocytosis, raised rhabdomyolysis-related indicators. Neuroleptic malignant syndrome was strongly suspected. After worsening of his neuropsychiatric conditions, with the onset of a frontal cognitive deficit, bradykinesia and difficulty walking, dysphagia, anorexia and hypoferraemic anaemia, SPET revealed a reduction of cerebral perfusion and ENeG results were compatible with a mainly motor polyneuropathy. Extensive laboratory investigations gave positive results for anti-gliadin antibodies, and an appropriate diet led to a progressive remission of the encephalopathy. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 33% |
Unknown | 4 | 67% |
Demographic breakdown
Type | Count | As % |
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Scientists | 3 | 50% |
Members of the public | 2 | 33% |
Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Senegal | 1 | 2% |
Unknown | 48 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 10 | 20% |
Student > Master | 7 | 14% |
Student > Ph. D. Student | 5 | 10% |
Professor > Associate Professor | 5 | 10% |
Student > Bachelor | 3 | 6% |
Other | 10 | 20% |
Unknown | 9 | 18% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 18 | 37% |
Nursing and Health Professions | 6 | 12% |
Biochemistry, Genetics and Molecular Biology | 3 | 6% |
Agricultural and Biological Sciences | 3 | 6% |
Psychology | 3 | 6% |
Other | 5 | 10% |
Unknown | 11 | 22% |