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HNF1B polymorphism influences the prognosis of endometrial cancer patients: a cohort study

Overview of attention for article published in BMC Cancer, April 2015
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Title
HNF1B polymorphism influences the prognosis of endometrial cancer patients: a cohort study
Published in
BMC Cancer, April 2015
DOI 10.1186/s12885-015-1246-5
Pubmed ID
Authors

Vincenzo Dario Mandato, Enrico Farnetti, Federica Torricelli, Martino Abrate, Bruno Casali, Gino Ciarlini, Debora Pirillo, Maria Carolina Gelli, Davide Nicoli, Mario Grassi, Giovanni Battista LA Sala, Stefano Palomba

Abstract

HNF1B (formerly known as TCF2) gene encodes for a transcription factor that regulates gene expression involved in normal mesodermal and endodermal developments. A close association between rs4430796 polymorphism of HNF1B gene and decreased endometrial cancer (EC) risk has been demonstrated. The aim of the current study was to test the hypothesis that rs4430796 polymorphism can influence the prognosis of EC patients. Retrospective cohort study. Clinical and pathological data were extrapolated and genotypes were assessed on formalin-fixed and paraffin-embedded non-tumour tissues. The influence of patients' genotype on overall survival and progression free survival were our main outcome measures. A total of 191 EC patients were included in the final analysis. Overall survival differed significantly (P = 0.003) among genotypes. At multivariate analysis, a significant (P < 0.05) effect on overall survival was detected for histology, myometrial invasion, FIGO stage, adjuvant therapy, and rs4430796 polymorphism of HNF1B gene. After grouping EC patients according to adjuvant treatment, rs4430796 polymorphism resulted significantly (P < 0.001) related to overall survival only (vs. radiotherapy alone) in subjects who received radiotherapy plus chemotherapy. A significant (P = 0.014) interaction between rs4430796 polymorphism and chemo-radiotherapy was also detected. Finally, only a trend (P = 0.090) towards significance was observed for rs4430796 polymorphism effect on progression free survival. rs4430796 polymorphism of HNF1B gene influences independently the prognosis of EC patients with a potential effect on tumor chemo-sensitivity.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 6%
Unknown 17 94%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 4 22%
Student > Bachelor 4 22%
Student > Ph. D. Student 2 11%
Student > Doctoral Student 1 6%
Other 1 6%
Other 4 22%
Unknown 2 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 33%
Medicine and Dentistry 5 28%
Sports and Recreations 1 6%
Agricultural and Biological Sciences 1 6%
Neuroscience 1 6%
Other 1 6%
Unknown 3 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 June 2016.
All research outputs
#20,334,427
of 22,879,161 outputs
Outputs from BMC Cancer
#6,505
of 8,325 outputs
Outputs of similar age
#224,078
of 264,845 outputs
Outputs of similar age from BMC Cancer
#222
of 259 outputs
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