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Intravital microscopy for evaluating tumor perfusion of nanoparticles exposed to non-invasive radiofrequency electric fields

Overview of attention for article published in Cancer Nanotechnology, June 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (61st percentile)

Mentioned by

twitter
5 tweeters

Citations

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11 Dimensions

Readers on

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18 Mendeley
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Title
Intravital microscopy for evaluating tumor perfusion of nanoparticles exposed to non-invasive radiofrequency electric fields
Published in
Cancer Nanotechnology, June 2016
DOI 10.1186/s12645-016-0016-7
Pubmed ID
Authors

Norman A. Lapin, Martyna Krzykawska-Serda, Matthew J. Ware, Steven A. Curley, Stuart J. Corr

Abstract

Poor biodistribution and accumulation of chemotherapeutics in tumors due to limitations on diffusive transport and high intra-tumoral pressures (Jain RK, Nat Med. 7(9):987-989, 2001) have prompted the investigation of adjunctive therapies to improve treatment outcomes. Hyperthermia has been widely applied in attempts to meet this need, but it is limited in its ability to reach tumors in deeply located body regions. High-intensity radiofrequency (RF) electric fields have the potential to overcome such barriers enhancing delivery and extravasation of chemotherapeutics. However, due to factors, including tumor heterogeneity and lack of kinetic information, there is insufficient understanding of time-resolved interaction between RF fields and tumor vasculature, drug molecules and nanoparticle (NP) vectors. Intravital microscopy (IVM) provides time-resolved high-definition images of specific tumor microenvironments, overcoming heterogeneity issues, and can be integrated with a portable RF device to enable detailed observation over time of the effects of the RF field on kinetics and biodistribution at the microvascular level. Herein, we provide a protocol describing the safe integration of IVM with a high-powered non-invasive RF field applied to 4T1 orthotopic breast tumors in live mice. Results show increased perfusion of NPs in microvasculature upon RF hyperthermia treatment and increased perfusion, release and spreading of injected reagents preferentially in irregular vessels during RF exposure.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Poland 1 6%
Unknown 17 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 39%
Professor > Associate Professor 2 11%
Student > Master 2 11%
Student > Ph. D. Student 2 11%
Unspecified 1 6%
Other 2 11%
Unknown 2 11%
Readers by discipline Count As %
Engineering 3 17%
Pharmacology, Toxicology and Pharmaceutical Science 2 11%
Medicine and Dentistry 2 11%
Chemistry 2 11%
Biochemistry, Genetics and Molecular Biology 1 6%
Other 4 22%
Unknown 4 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 July 2016.
All research outputs
#8,372,088
of 16,122,290 outputs
Outputs from Cancer Nanotechnology
#37
of 78 outputs
Outputs of similar age
#100,747
of 263,825 outputs
Outputs of similar age from Cancer Nanotechnology
#1
of 1 outputs
Altmetric has tracked 16,122,290 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 78 research outputs from this source. They receive a mean Attention Score of 3.7. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,825 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them