Dnmt3b regulates DUX4 expression in a tissue-dependent manner in transgenic #D4Z4 mice > loss of Dnmt3b results in derepression of DUX4 in lymphoid tissues and mESCs but not in myogenic cells of D4Z4-2.5/Dnmt3bMommeD14 mice > https://t.co/OlqoOfTJ
RT @davidjglassMD: FSHD is a genetic disease caused by derepression of the transcription factor DUX4 in skeletal muscle. DNMT3B was recentl…
FSHD is a genetic disease caused by derepression of the transcription factor DUX4 in skeletal muscle. DNMT3B was recently identified as a disease gene and disease modifier in FSHD. This shows loss of Dnmt3b derepresses DUX4 in lymphoid tissues and mESCs.
RT @MuscleStemCell: Dnmt3b regulates DUX4 expression in a tissue-dependent manner in transgenic D4Z4 mice. https://t.co/z8oMct6MjL