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X Demographics
Mendeley readers
| Title |
Combination therapy in cancer: effects of angiogenesis inhibitors on drug pharmacokinetics and pharmacodynamics
|
|---|---|
| Published in |
Cancer Communications, June 2016
|
| DOI | 10.1186/s40880-016-0123-1 |
| Pubmed ID | |
| Authors |
Ilaria Fuso Nerini, Marta Cesca, Francesca Bizzaro, Raffaella Giavazzi |
| Abstract |
Validated preclinical studies have provided evidence that anti-vascular endothelial growth factor (VEGF) compounds enhance the activity of subsequent antitumor therapy, but the mechanism of this potentiation is far from clear. The most widespread explanation is enhanced delivery of therapeutics due to vascular remodeling, lower interstitial pressure, and increased blood flow. While the antiangiogenic effects on vascular morphology have been fairly consistent in both preclinical and clinical settings, the improvement of tumor vessel function is debated. This review focuses on the effect of anti-VEGF therapy on tumor microenvironment morphology and functions, and its therapeutic benefits when combined with other therapies. The uptake and spatial distribution of chemotherapeutic agents into the tumor after anti-VEGF are examined. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 45 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 12 | 27% |
| Student > Ph. D. Student | 7 | 16% |
| Student > Doctoral Student | 4 | 9% |
| Researcher | 4 | 9% |
| Student > Bachelor | 3 | 7% |
| Other | 9 | 20% |
| Unknown | 6 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 22% |
| Medicine and Dentistry | 8 | 18% |
| Agricultural and Biological Sciences | 8 | 18% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 11% |
| Nursing and Health Professions | 2 | 4% |
| Other | 3 | 7% |
| Unknown | 9 | 20% |