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Nasopharyngeal microbiota composition of children is related to the frequency of upper respiratory infection and acute sinusitis

Overview of attention for article published in Microbiome, July 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • Average Attention Score compared to outputs of the same age and source

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1 blog
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13 X users
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2 patents
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1 Google+ user

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114 Mendeley
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Title
Nasopharyngeal microbiota composition of children is related to the frequency of upper respiratory infection and acute sinusitis
Published in
Microbiome, July 2016
DOI 10.1186/s40168-016-0179-9
Pubmed ID
Authors

Clark A. Santee, Nabeetha A. Nagalingam, Ali A. Faruqi, Gregory P. DeMuri, James E. Gern, Ellen R. Wald, Susan V. Lynch

Abstract

Upper respiratory infections (URI) and their complications are a major healthcare burden for pediatric populations. Although the microbiology of the nasopharynx is an important determinant of the complications of URI, little is known of the nasopharyngeal (NP) microbiota of children, the factors that affect its composition, and its precise relationship with URI. Healthy children (n = 47) aged 49-84 months from a prospective cohort study based in Wisconsin, USA, were examined. Demographic and clinical data and NP swab samples were obtained from participants upon entry to the study. All NP samples were profiled for bacterial microbiota using a phylogenetic microarray, and these data were related to demographic characteristics and upper respiratory health outcomes. The composition of the NP bacterial community of children was significantly related prior to the history of acute sinusitis (R (2) = 0.070, P < 0.009). History of acute sinusitis was associated with significant depletion in relative abundance of taxa including Faecalibacterium prausnitzii and Akkermansia spp. and enrichment of Moraxella nonliquefaciens. Enrichment of M. nonliquefaciens was also a characteristic of baseline NP samples of children who subsequently developed acute sinusitis over the 1-year study period. Time to develop URI was significantly positively correlated with NP diversity, and children who experienced more frequent URIs exhibited significantly diminished NP microbiota diversity (P ≤ 0.05). These preliminary data suggest that previous history of acute sinusitis influences the composition of the NP microbiota, characterized by a depletion in relative abundance of specific taxa. Diminished diversity was associated with more frequent URIs.

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X Demographics

The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 114 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 114 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 16%
Researcher 17 15%
Student > Master 12 11%
Student > Bachelor 10 9%
Other 7 6%
Other 14 12%
Unknown 36 32%
Readers by discipline Count As %
Medicine and Dentistry 25 22%
Agricultural and Biological Sciences 21 18%
Immunology and Microbiology 12 11%
Biochemistry, Genetics and Molecular Biology 10 9%
Nursing and Health Professions 3 3%
Other 6 5%
Unknown 37 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 August 2022.
All research outputs
#1,597,212
of 23,053,169 outputs
Outputs from Microbiome
#621
of 1,461 outputs
Outputs of similar age
#31,034
of 352,703 outputs
Outputs of similar age from Microbiome
#16
of 23 outputs
Altmetric has tracked 23,053,169 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,461 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 40.4. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,703 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.