Title |
Rift Valley fever virus NSs protein functions and the similarity to other bunyavirus NSs proteins
|
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Published in |
Virology Journal, July 2016
|
DOI | 10.1186/s12985-016-0573-8 |
Pubmed ID | |
Authors |
Hoai J. Ly, Tetsuro Ikegami |
Abstract |
Rift Valley fever is a mosquito-borne zoonotic disease that affects both ruminants and humans. The nonstructural (NS) protein, which is a major virulence factor for Rift Valley fever virus (RVFV), is encoded on the S-segment. Through the cullin 1-Skp1-Fbox E3 ligase complex, the NSs protein promotes the degradation of at least two host proteins, the TFIIH p62 and the PKR proteins. NSs protein bridges the Fbox protein with subsequent substrates, and facilitates the transfer of ubiquitin. The SAP30-YY1 complex also bridges the NSs protein with chromatin DNA, affecting cohesion and segregation of chromatin DNA as well as the activation of interferon-β promoter. The presence of NSs filaments in the nucleus induces DNA damage responses and causes cell-cycle arrest, p53 activation, and apoptosis. Despite the fact that NSs proteins have poor amino acid similarity among bunyaviruses, the strategy utilized to hijack host cells are similar. This review will provide and summarize an update of recent findings pertaining to the biological functions of the NSs protein of RVFV as well as the differences from those of other bunyaviruses. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 20% |
France | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 60% |
Scientists | 1 | 20% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | <1% |
Unknown | 127 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 24 | 19% |
Student > Bachelor | 19 | 15% |
Researcher | 19 | 15% |
Student > Master | 16 | 13% |
Professor | 6 | 5% |
Other | 18 | 14% |
Unknown | 26 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 32 | 25% |
Biochemistry, Genetics and Molecular Biology | 29 | 23% |
Immunology and Microbiology | 17 | 13% |
Veterinary Science and Veterinary Medicine | 6 | 5% |
Medicine and Dentistry | 5 | 4% |
Other | 11 | 9% |
Unknown | 28 | 22% |