Title |
Narrowing down the role of common variants in the genetic predisposition to obesity
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Published in |
Genome Medicine, March 2009
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DOI | 10.1186/gm31 |
Pubmed ID | |
Authors |
Melissa A Calton, Christian Vaisse |
Abstract |
The extent to which common variants contribute to common phenotypes and disease in humans has important consequences for the future of medical genomics. Two reports have recently clarified this issue for one of the most pressing public health concerns, obesity. These large and comprehensive genome-wide association studies find that common variants within at least 11 genes are associated with obesity. Interestingly, most of these genes are highly expressed in the central nervous system, further highlighting its role in the pathogenesis of obesity. However, the individual and combined effects of these variants explain only a small fraction of the inherited variability in obesity, suggesting that rare variants may contribute significantly to the genetic predisposition for this condition. |
X Demographics
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 4% |
United States | 1 | 4% |
Unknown | 21 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 7 | 30% |
Student > Ph. D. Student | 6 | 26% |
Student > Master | 3 | 13% |
Student > Bachelor | 2 | 9% |
Student > Doctoral Student | 1 | 4% |
Other | 1 | 4% |
Unknown | 3 | 13% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 10 | 43% |
Biochemistry, Genetics and Molecular Biology | 4 | 17% |
Medicine and Dentistry | 2 | 9% |
Nursing and Health Professions | 1 | 4% |
Mathematics | 1 | 4% |
Other | 2 | 9% |
Unknown | 3 | 13% |