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MicroRNA-506 is up-regulated in the development of pancreatic ductal adenocarcinoma and is associated with attenuated disease progression

Overview of attention for article published in Ai zheng Aizheng Chinese journal of cancer, July 2016
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Title
MicroRNA-506 is up-regulated in the development of pancreatic ductal adenocarcinoma and is associated with attenuated disease progression
Published in
Ai zheng Aizheng Chinese journal of cancer, July 2016
DOI 10.1186/s40880-016-0128-9
Pubmed ID
Authors

Run-Fen Cheng, Jian Wang, Jing-Yi Zhang, Lin Sun, Yan-Rui Zhao, Zhi-Qiang Qiu, Bao-Cun Sun, Yan Sun

Abstract

MicroRNA-506 (miR-506) has been reported to function in several tumors as a tumor suppressor gene or oncogene. However, the expression and role of miR-506 in pancreatic ductal adenocarcinoma (PDAC) remains unclear. In this study, we aimed to evaluate the phenotype of miR-506 in PDAC. Using miRNA in situ hybridization, we examined the expression of miR-506 in 113 PDACs and 87 paired normal pancreatic tissues. We evaluated miR-506 expression in PDAC cells, normal pancreatic ducts, and acinus/islands, and we analyzed the associations between miR-506 expression and the clinicopathologic characteristics of PDAC patients. miR-506 expression was higher in PDAC than in matched normal pancreatic ductal cells (P < 0.001). On the other hand, the combined group of well and moderately differentiated PDACs showed higher levels of miR-506 than the poorly differentiated ones (P = 0.023). Moreover, miR-506 expression was negatively associated with pathologic T category (P = 0.004) and lymph node metastasis (P = 0.033), suggesting that miR-506 might inhibit the progression of PDAC. Our results suggest that miR-506 either plays a role as an oncogene in the tumorigenesis and a tumor suppressor in the progression or serves as a house-keeping, tumor-suppressing miRNA, whose expression can be activated by oncogenic signals in early development to hinder the progression of PDAC.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 25%
Student > Ph. D. Student 2 17%
Researcher 2 17%
Student > Master 1 8%
Other 1 8%
Other 0 0%
Unknown 3 25%
Readers by discipline Count As %
Medicine and Dentistry 6 50%
Biochemistry, Genetics and Molecular Biology 1 8%
Neuroscience 1 8%
Agricultural and Biological Sciences 1 8%
Unknown 3 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2016.
All research outputs
#6,905,305
of 7,981,790 outputs
Outputs from Ai zheng Aizheng Chinese journal of cancer
#119
of 162 outputs
Outputs of similar age
#218,689
of 260,423 outputs
Outputs of similar age from Ai zheng Aizheng Chinese journal of cancer
#13
of 17 outputs
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So far Altmetric has tracked 162 research outputs from this source. They receive a mean Attention Score of 2.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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