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Molecular pathways leading to loss of skeletal muscle mass in cancer cachexia – can findings from animal models be translated to humans?

Overview of attention for article published in BMC Cancer, February 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

news
2 news outlets
twitter
3 X users
video
1 YouTube creator

Citations

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72 Dimensions

Readers on

mendeley
152 Mendeley
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1 CiteULike
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Title
Molecular pathways leading to loss of skeletal muscle mass in cancer cachexia – can findings from animal models be translated to humans?
Published in
BMC Cancer, February 2016
DOI 10.1186/s12885-016-2121-8
Pubmed ID
Authors

Tara C. Mueller, Jeannine Bachmann, Olga Prokopchuk, Helmut Friess, Marc E. Martignoni

Abstract

Cachexia is a multi-factorial, systemic syndrome that especially affects patients with cancer of the gastrointestinal tract, and leads to reduced treatment response, survival and quality of life. The most important clinical feature of cachexia is the excessive wasting of skeletal muscle mass. Currently, an effective treatment is still lacking and the search for therapeutic targets continues. Even though a substantial number of animal studies have contributed to a better understanding of the underlying mechanisms of the loss of skeletal muscle mass, subsequent clinical trials of potential new drugs have not yet yielded any effective treatment for cancer cachexia. Therefore, we questioned to which degree findings from animal studies can be translated to humans in clinical practice and research. A substantial amount of animal studies on the molecular mechanisms of muscle wasting in cancer cachexia has been conducted in recent years. This extensive review of the literature showed that most of their observations could not be consistently reproduced in studies on human skeletal muscle samples. However, studies on human material are scarce and limited in patient numbers and homogeneity. Therefore, their results have to be interpreted critically. More research is needed on human tissue samples to clarify the signaling pathways that lead to skeletal muscle loss, and to confirm pre-selected drug targets from animal models in clinical trials. In addition, improved diagnostic tools and standardized clinical criteria for cancer cachexia are needed to conduct standardized, randomized controlled trials of potential drug candidates in the future.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 152 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Poland 1 <1%
Brazil 1 <1%
Unknown 150 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 29 19%
Student > Ph. D. Student 27 18%
Researcher 21 14%
Student > Bachelor 16 11%
Student > Doctoral Student 9 6%
Other 23 15%
Unknown 27 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 35 23%
Medicine and Dentistry 32 21%
Agricultural and Biological Sciences 28 18%
Nursing and Health Professions 6 4%
Sports and Recreations 6 4%
Other 11 7%
Unknown 34 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 August 2023.
All research outputs
#1,944,430
of 24,535,155 outputs
Outputs from BMC Cancer
#299
of 8,711 outputs
Outputs of similar age
#34,989
of 408,571 outputs
Outputs of similar age from BMC Cancer
#9
of 188 outputs
Altmetric has tracked 24,535,155 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,711 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 408,571 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 188 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.