Title |
TFinDit: transcription factor-DNA interaction data depository
|
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Published in |
BMC Bioinformatics, September 2012
|
DOI | 10.1186/1471-2105-13-220 |
Pubmed ID | |
Authors |
Daniel Turner, RyangGuk Kim, Jun-tao Guo |
Abstract |
One of the crucial steps in regulation of gene expression is the binding of transcription factor(s) to specific DNA sequences. Knowledge of the binding affinity and specificity at a structural level between transcription factors and their target sites has important implications in our understanding of the mechanism of gene regulation. Due to their unique functions and binding specificity, there is a need for a transcription factor-specific, structure-based database and corresponding web service to facilitate structural bioinformatics studies of transcription factor-DNA interactions, such as development of knowledge-based interaction potential, transcription factor-DNA docking, binding induced conformational changes, and the thermodynamics of protein-DNA interactions. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 5% |
Spain | 1 | 5% |
United States | 1 | 5% |
Germany | 1 | 5% |
Unknown | 16 | 80% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 25% |
Student > Ph. D. Student | 5 | 25% |
Professor | 3 | 15% |
Student > Doctoral Student | 2 | 10% |
Student > Postgraduate | 2 | 10% |
Other | 3 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 15 | 75% |
Computer Science | 2 | 10% |
Biochemistry, Genetics and Molecular Biology | 2 | 10% |
Unknown | 1 | 5% |