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Antibiotics for bronchiectasis exacerbations in children: rationale and study protocol for a randomised placebo-controlled trial

Overview of attention for article published in Trials, August 2012
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Title
Antibiotics for bronchiectasis exacerbations in children: rationale and study protocol for a randomised placebo-controlled trial
Published in
Trials, August 2012
DOI 10.1186/1745-6215-13-156
Pubmed ID
Authors

Anne B Chang, Keith Grimwood, Colin F Robertson, Andrew C Wilson, Peter P van Asperen, Kerry-Ann F O’Grady, Theo P Sloots, Paul J Torzillo, Emily J Bailey, Gabrielle B McCallum, Ian B Masters, Catherine A Byrnes, Mark D Chatfield, Helen M Buntain, Ian M Mackay, Peter S Morris

Abstract

Despite bronchiectasis being increasingly recognised as an important cause of chronic respiratory morbidity in both indigenous and non-indigenous settings globally, high quality evidence to inform management is scarce. It is assumed that antibiotics are efficacious for all bronchiectasis exacerbations, but not all practitioners agree. Inadequately treated exacerbations may risk lung function deterioration. Our study tests the hypothesis that both oral azithromycin and amoxicillin-clavulanic acid are superior to placebo at improving resolution rates of respiratory exacerbations by day 14 in children with bronchiectasis unrelated to cystic fibrosis.

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Mendeley readers

The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Spain 1 1%
Canada 1 1%
Unknown 97 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 14%
Researcher 14 14%
Student > Bachelor 11 11%
Student > Master 9 9%
Other 9 9%
Other 19 19%
Unknown 24 24%
Readers by discipline Count As %
Medicine and Dentistry 36 36%
Nursing and Health Professions 8 8%
Pharmacology, Toxicology and Pharmaceutical Science 8 8%
Agricultural and Biological Sciences 7 7%
Biochemistry, Genetics and Molecular Biology 3 3%
Other 13 13%
Unknown 25 25%