Title |
Antibiotics for bronchiectasis exacerbations in children: rationale and study protocol for a randomised placebo-controlled trial
|
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Published in |
Trials, August 2012
|
DOI | 10.1186/1745-6215-13-156 |
Pubmed ID | |
Authors |
Anne B Chang, Keith Grimwood, Colin F Robertson, Andrew C Wilson, Peter P van Asperen, Kerry-Ann F O’Grady, Theo P Sloots, Paul J Torzillo, Emily J Bailey, Gabrielle B McCallum, Ian B Masters, Catherine A Byrnes, Mark D Chatfield, Helen M Buntain, Ian M Mackay, Peter S Morris |
Abstract |
Despite bronchiectasis being increasingly recognised as an important cause of chronic respiratory morbidity in both indigenous and non-indigenous settings globally, high quality evidence to inform management is scarce. It is assumed that antibiotics are efficacious for all bronchiectasis exacerbations, but not all practitioners agree. Inadequately treated exacerbations may risk lung function deterioration. Our study tests the hypothesis that both oral azithromycin and amoxicillin-clavulanic acid are superior to placebo at improving resolution rates of respiratory exacerbations by day 14 in children with bronchiectasis unrelated to cystic fibrosis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
Spain | 1 | 1% |
Canada | 1 | 1% |
Unknown | 97 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 14% |
Researcher | 14 | 14% |
Student > Bachelor | 11 | 11% |
Student > Master | 9 | 9% |
Other | 9 | 9% |
Other | 19 | 19% |
Unknown | 24 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 36 | 36% |
Nursing and Health Professions | 8 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 8% |
Agricultural and Biological Sciences | 7 | 7% |
Biochemistry, Genetics and Molecular Biology | 3 | 3% |
Other | 13 | 13% |
Unknown | 25 | 25% |