You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Genomics and pharmacogenomics of sepsis: so close and yet so far
|
|---|---|
| Published in |
Critical Care, July 2016
|
| DOI | 10.1186/s13054-016-1374-6 |
| Pubmed ID | |
| Authors |
James A. Russell |
| Abstract |
Sapru et al. show in this issue of Critical Care that variants of thrombomodulin and the endothelial protein C receptor, but not protein C, are associated with mortality and organ dysfunction (ventilation-free and organ failure-free days) in ARDS. Hundreds of gene variants have been found prognostic in sepsis. However, none of these prognostic genomic biomarkers are used clinically. Predictive biomarker discovery (pharmacogenomics) usually follows a candidate gene approach, utilizing knowledge of drug pathways. Pharmacogenomics could be applied to enhance efficacy and safety of drugs used for treatment of sepsis (e.g., norepinephrine, epinephrine, vasopressin, and corticosteroids). Pharmacogenomics can enhance drug development in sepsis, which is very important because there is no approved drug for sepsis. Pharmacogenomics biomarkers must pass three milestones: scientific, regulatory, and commercial. Huge challenges remain but great opportunities for pharmacogenomics of sepsis are on the horizon. |
X Demographics
The data shown below were collected from the profiles of 34 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 15% |
| United Kingdom | 4 | 12% |
| Spain | 3 | 9% |
| Netherlands | 2 | 6% |
| Mexico | 1 | 3% |
| Russia | 1 | 3% |
| Belarus | 1 | 3% |
| South Africa | 1 | 3% |
| Colombia | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 13 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 21 | 62% |
| Scientists | 6 | 18% |
| Practitioners (doctors, other healthcare professionals) | 6 | 18% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Russia | 1 | 1% |
| South Africa | 1 | 1% |
| Unknown | 68 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 11% |
| Researcher | 7 | 10% |
| Student > Bachelor | 5 | 7% |
| Other | 5 | 7% |
| Student > Ph. D. Student | 5 | 7% |
| Other | 9 | 13% |
| Unknown | 31 | 44% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 18 | 26% |
| Biochemistry, Genetics and Molecular Biology | 7 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 6% |
| Agricultural and Biological Sciences | 3 | 4% |
| Nursing and Health Professions | 1 | 1% |
| Other | 6 | 9% |
| Unknown | 31 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2018.
All research outputs
#1,840,714
of 25,374,917 outputs
Outputs from Critical Care
#1,637
of 6,554 outputs
Outputs of similar age
#33,102
of 371,009 outputs
Outputs of similar age from Critical Care
#61
of 120 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 371,009 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 120 others from the same source and published within six weeks on either side of this one. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.