Title |
Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation
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Published in |
Journal of Neuroinflammation, June 2011
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DOI | 10.1186/1742-2094-8-64 |
Pubmed ID | |
Authors |
Pratibha V Nerurkar, Lisa M Johns, Lance M Buesa, Gideon Kipyakwai, Esther Volper, Ryuei Sato, Pranjal Shah, Domonkos Feher, Philip G Williams, Vivek R Nerurkar |
Abstract |
The rising epidemic of obesity is associated with cognitive decline and is considered as one of the major risk factors for neurodegenerative diseases. Neuroinflammation is a critical component in the progression of several neurological and neurodegenerative diseases. Increased metabolic flux to the brain during overnutrition and obesity can orchestrate stress response, blood-brain barrier (BBB) disruption, recruitment of inflammatory immune cells from peripheral blood and microglial cells activation leading to neuroinflammation. The lack of an effective treatment for obesity-associated brain dysfunction may have far-reaching public health ramifications, urgently necessitating the identification of appropriate preventive and therapeutic strategies. The objective of our study was to investigate the neuroprotective effects of Momordica charantia (bitter melon) on high-fat diet (HFD)-associated BBB disruption, stress and neuroinflammatory cytokines. |
X Demographics
Geographical breakdown
Country | Count | As % |
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India | 2 | 22% |
United States | 1 | 11% |
Spain | 1 | 11% |
Thailand | 1 | 11% |
Canada | 1 | 11% |
Unknown | 3 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 9 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
Netherlands | 1 | <1% |
Unknown | 165 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 28 | 17% |
Student > Master | 27 | 16% |
Student > Bachelor | 27 | 16% |
Researcher | 14 | 8% |
Student > Postgraduate | 8 | 5% |
Other | 30 | 18% |
Unknown | 33 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 39 | 23% |
Medicine and Dentistry | 17 | 10% |
Neuroscience | 16 | 10% |
Biochemistry, Genetics and Molecular Biology | 14 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 5% |
Other | 28 | 17% |
Unknown | 45 | 27% |