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Oxidative stress and the use of antioxidants in diabetes: Linking basic science to clinical practice

Overview of attention for article published in Cardiovascular Diabetology, April 2005
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Citations

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623 Mendeley
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1 CiteULike
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Title
Oxidative stress and the use of antioxidants in diabetes: Linking basic science to clinical practice
Published in
Cardiovascular Diabetology, April 2005
DOI 10.1186/1475-2840-4-5
Pubmed ID
Authors

Jeanette Schultz Johansen, Alex K Harris, David J Rychly, Adviye Ergul

Abstract

Cardiovascular complications, characterized by endothelial dysfunction and accelerated atherosclerosis, are the leading cause of morbidity and mortality associated with diabetes. There is growing evidence that excess generation of highly reactive free radicals, largely due to hyperglycemia, causes oxidative stress, which further exacerbates the development and progression of diabetes and its complications. Overproduction and/or insufficient removal of these free radicals result in vascular dysfunction, damage to cellular proteins, membrane lipids and nucleic acids. Despite overwhelming evidence on the damaging consequences of oxidative stress and its role in experimental diabetes, large scale clinical trials with classic antioxidants failed to demonstrate any benefit for diabetic patients. As our understanding of the mechanisms of free radical generation evolves, it is becoming clear that rather than merely scavenging reactive radicals, a more comprehensive approach aimed at preventing the generation of these reactive species as well as scavenging may prove more beneficial. Therefore, new strategies with classic as well as new antioxidants should be implemented in the treatment of diabetes.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 623 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 <1%
Mexico 3 <1%
Indonesia 1 <1%
France 1 <1%
United Kingdom 1 <1%
India 1 <1%
South Africa 1 <1%
Spain 1 <1%
Nigeria 1 <1%
Other 2 <1%
Unknown 608 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 105 17%
Student > Ph. D. Student 99 16%
Researcher 52 8%
Student > Bachelor 52 8%
Student > Postgraduate 32 5%
Other 132 21%
Unknown 151 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 129 21%
Medicine and Dentistry 95 15%
Biochemistry, Genetics and Molecular Biology 64 10%
Chemistry 39 6%
Pharmacology, Toxicology and Pharmaceutical Science 38 6%
Other 78 13%
Unknown 180 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 May 2012.
All research outputs
#20,166,700
of 22,678,224 outputs
Outputs from Cardiovascular Diabetology
#1,199
of 1,363 outputs
Outputs of similar age
#56,156
of 57,855 outputs
Outputs of similar age from Cardiovascular Diabetology
#3
of 3 outputs
Altmetric has tracked 22,678,224 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,363 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 57,855 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.