Title |
Multimodal hypoxia imaging and intensity modulated radiation therapy for unresectable non-small-cell lung cancer: the HIL trial
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Published in |
Radiation Oncology, September 2012
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DOI | 10.1186/1748-717x-7-157 |
Pubmed ID | |
Authors |
Vasileios Askoxylakis, Julien Dinkel, Monika Eichinger, Bram Stieltjes, Gregor Sommer, Ludwig G Strauss, Antonia Dimitrakopoulou-Strauss, Annette Kopp-Schneider, Uwe Haberkorn, Peter E Huber, Marc Bischof, Jürgen Debus, Christian Thieke |
Abstract |
Radiotherapy, preferably combined with chemotherapy, is the treatment standard for locally advanced, unresectable non-small cell lung cancer (NSCLC). The tumor response to different therapy protocols is variable, with hypoxia known to be a major factor that negatively influences treatment effectiveness. Visualisation of tumor hypoxia prior to the use of modern radiation therapy strategies, such as intensity modulated radiation therapy (IMRT), might allow optimized dose applications to the target volume, leading to improvement of therapy outcome. (18)F-fluoromisonidazole dynamic positron emission tomography and computed tomography ((18) F-FMISO dPET-CT) and functional magnetic resonance imaging (functional MRI) are attractive options for imaging tumor hypoxia. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 2% |
United States | 1 | 2% |
Unknown | 51 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 9 | 17% |
Student > Master | 5 | 9% |
Student > Ph. D. Student | 4 | 8% |
Student > Doctoral Student | 3 | 6% |
Student > Bachelor | 3 | 6% |
Other | 14 | 26% |
Unknown | 15 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 18 | 34% |
Agricultural and Biological Sciences | 4 | 8% |
Physics and Astronomy | 4 | 8% |
Nursing and Health Professions | 3 | 6% |
Social Sciences | 2 | 4% |
Other | 5 | 9% |
Unknown | 17 | 32% |