Title |
Current status and perspectives of Clonorchis sinensis and clonorchiasis: epidemiology, pathogenesis, omics, prevention and control
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Published in |
Infectious Diseases of Poverty, July 2016
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DOI | 10.1186/s40249-016-0166-1 |
Pubmed ID | |
Authors |
Ze-Li Tang, Yan Huang, Xin-Bing Yu |
Abstract |
Clonorchiasis, caused by Clonorchis sinensis (C. sinensis), is an important food-borne parasitic disease and one of the most common zoonoses. Currently, it is estimated that more than 200 million people are at risk of C. sinensis infection, and over 15 million are infected worldwide. C. sinensis infection is closely related to cholangiocarcinoma (CCA), fibrosis and other human hepatobiliary diseases; thus, clonorchiasis is a serious public health problem in endemic areas. This article reviews the current knowledge regarding the epidemiology, disease burden and treatment of clonorchiasis as well as summarizes the techniques for detecting C. sinensis infection in humans and intermediate hosts and vaccine development against clonorchiasis. Newer data regarding the pathogenesis of clonorchiasis and the genome, transcriptome and secretome of C. sinensis are collected, thus providing perspectives for future studies. These advances in research will aid the development of innovative strategies for the prevention and control of clonorchiasis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 137 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 20 | 15% |
Researcher | 15 | 11% |
Student > Master | 15 | 11% |
Student > Ph. D. Student | 9 | 7% |
Lecturer | 6 | 4% |
Other | 14 | 10% |
Unknown | 58 | 42% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 23 | 17% |
Biochemistry, Genetics and Molecular Biology | 15 | 11% |
Veterinary Science and Veterinary Medicine | 10 | 7% |
Agricultural and Biological Sciences | 8 | 6% |
Immunology and Microbiology | 6 | 4% |
Other | 14 | 10% |
Unknown | 61 | 45% |