Title |
Enhancement of proinflammatory and procoagulant responses to silica particles by monocyte-endothelial cell interactions
|
---|---|
Published in |
Particle and Fibre Toxicology, September 2012
|
DOI | 10.1186/1743-8977-9-36 |
Pubmed ID | |
Authors |
Xin Liu, Yang Xue, Tingting Ding, Jiao Sun |
Abstract |
Inorganic particles, such as drug carriers or contrast agents, are often introduced into the vascular system. Many key components of the in vivo vascular environment include monocyte-endothelial cell interactions, which are important in the initiation of cardiovascular disease. To better understand the effect of particles on vascular function, the present study explored the direct biological effects of particles on human umbilical vein endothelial cells (HUVECs) and monocytes (THP-1 cells). In addition, the integrated effects and possible mechanism of particle-mediated monocyte-endothelial cell interactions were investigated using a coculture model of HUVECs and THP-1 cells. Fe₃O₄ and SiO₂ particles were chosen as the test materials in the present study. |
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Demographic breakdown
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Mendeley readers
Geographical breakdown
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Researcher | 9 | 20% |
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Student > Master | 6 | 13% |
Student > Bachelor | 3 | 7% |
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Unknown | 6 | 13% |
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Biochemistry, Genetics and Molecular Biology | 3 | 7% |
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