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Pre-diagnostic body mass index and weight change in relation to colorectal cancer survival among incident cases from a population-based cohort study

Overview of attention for article published in BMC Cancer, July 2016
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Title
Pre-diagnostic body mass index and weight change in relation to colorectal cancer survival among incident cases from a population-based cohort study
Published in
BMC Cancer, July 2016
DOI 10.1186/s12885-016-2445-4
Pubmed ID
Authors

Ida Laake, Inger K. Larsen, Randi Selmer, Inger Thune, Marit B. Veierød

Abstract

Whether excess body weight influences colorectal cancer (CRC) survival is unclear. We studied pre-diagnostic body mass index (BMI) and weight change in relation to CRC-specific mortality among incident CRC cases within a large, Norwegian cohort. Participants' weight was measured at health examinations up to three times between 1974 and 1988. CRC cases were identified through linkage with the Norwegian Cancer Registry. In total, 1336 men and 1180 women with a weight measurement >3 years prior to diagnosis were included in analyses. Hazard ratios (HRs) and confidence intervals (CIs) were estimated with Cox regression. During a mean follow-up of 5.8 years, 507 men and 432 women died from CRC. Obesity (BMI ≥30 kg/m(2)) was associated with higher CRC-specific mortality than normal weight (BMI 18.5-25 kg/m(2)) in men with proximal colon cancer, HR = 1.85 (95 % CI 1.08-3.16) and in women with rectal cancer, HR = 1.93 (95 % CI 1.13-3.30). Weight gain was associated with higher CRC-specific mortality in women with CRC, colon cancer, and distal colon cancer, HRs per 5 kg weight gain were 1.18 (95 % CI 1.01-1.37), 1.22 (95 % CI 1.02-1.45), and 1.40 (95 % CI 1.01-1.95), respectively. Weight gain was not significantly associated with survival in men. Maintaining a healthy weight may benefit CRC survival, at least in women.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 19%
Researcher 4 19%
Student > Bachelor 3 14%
Lecturer 2 10%
Other 1 5%
Other 4 19%
Unknown 3 14%
Readers by discipline Count As %
Medicine and Dentistry 9 43%
Biochemistry, Genetics and Molecular Biology 2 10%
Nursing and Health Professions 2 10%
Mathematics 1 5%
Psychology 1 5%
Other 1 5%
Unknown 5 24%