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Small interfering RNA-mediated suppression of Ccl2 in Müller cells attenuates microglial recruitment and photoreceptor death following retinal degeneration

Overview of attention for article published in Journal of Neuroinflammation, September 2012
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Title
Small interfering RNA-mediated suppression of Ccl2 in Müller cells attenuates microglial recruitment and photoreceptor death following retinal degeneration
Published in
Journal of Neuroinflammation, September 2012
DOI 10.1186/1742-2094-9-221
Pubmed ID
Authors

Matt Rutar, Riccardo Natoli, Jan M Provis

Abstract

The recruitment and activation of inflammatory cells is thought to exacerbate photoreceptor death in retinal degenerative conditions such as age-related macular degeneration (AMD). We investigated the role of Müller cell-derived chemokine (C-C motif) ligand (Ccl)2 expression on monocyte/microglia infiltration and photoreceptor death in light-mediated retinal degeneration, using targeted small interfering (si)RNA.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 1%
Unknown 68 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 20%
Student > Ph. D. Student 13 19%
Student > Master 7 10%
Student > Bachelor 7 10%
Professor 5 7%
Other 13 19%
Unknown 10 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 20%
Biochemistry, Genetics and Molecular Biology 14 20%
Neuroscience 10 14%
Medicine and Dentistry 9 13%
Immunology and Microbiology 5 7%
Other 5 7%
Unknown 12 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 September 2012.
All research outputs
#18,819,867
of 23,322,966 outputs
Outputs from Journal of Neuroinflammation
#2,114
of 2,695 outputs
Outputs of similar age
#130,918
of 171,833 outputs
Outputs of similar age from Journal of Neuroinflammation
#28
of 38 outputs
Altmetric has tracked 23,322,966 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,695 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 171,833 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.