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Anemia and the onset of gout in a population-based cohort of adults: Atherosclerosis Risk in Communities study

Overview of attention for article published in Arthritis Research & Therapy, August 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

news
1 news outlet
twitter
7 X users
wikipedia
1 Wikipedia page

Citations

dimensions_citation
24 Dimensions

Readers on

mendeley
54 Mendeley
citeulike
1 CiteULike
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Title
Anemia and the onset of gout in a population-based cohort of adults: Atherosclerosis Risk in Communities study
Published in
Arthritis Research & Therapy, August 2012
DOI 10.1186/ar4026
Pubmed ID
Authors

Mara A McAdams-DeMarco, Janet W Maynard, Josef Coresh, Alan N Baer

Abstract

ABSTRACT: INTRODUCTION: There is a growing prevalence of gout in the US and worldwide. Gout is a recognized risk factor for cardiovascular disease (CVD). It is unclear whether other risk factors for CVD are also associated with increased risk of gout. Anemia is one such CVD risk factor. No studies have evaluated the relationship between anemia and gout. We tested whether anemia was associated with incident gout independent of comorbid conditions in Atherosclerosis Risk in the Communities. METHODS: This population-based cohort recruited 15,792 individuals in 1987 to 1989 from four US communities and contained nine years of follow-up. Anemia was defined as hemoglobin <13.5 g/dL for men and <12 g/dL for women. Using a Cox Proportional Hazards model, we estimated the hazard ratio (HR) and confidence intervals (CI) of incident gout by baseline anemia, adjusted for confounders (sex, race, estimated glomerular filtration rate, body mass index and alcohol intake) and clinical factors (coronary heart disease, congestive heart failure, diabetes, hypertension, diuretic use and serum urate level). RESULTS: Among the 10,791 participants, 10% had anemia at baseline. There were 271 cases of incident gout. Patients with anemia had a two-fold increased risk of developing gout over nine years (HR = 2.01, 95% CI: 1.46, 2.76). Anemia was associated with incident gout independent of known gout risk factors, confounders and clinical risk factors (HR = 1.73, 95% CI: 1.24, 2.41). This association persisted after additionally adjusting for serum urate level (HR = 1.83, 95% CI: 1.30, 2.57). CONCLUSION: We identified anemia as a novel risk factor for gout. Anemia was associated with an approximately two-fold increased risk of gout-independent kidney function and serum urate. These findings suggest that anemia is a risk factor for gout on par with other chronic conditions such as obesity and diabetes. The biological mechanism linking anemia to gout remains unclear.

X Demographics

X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 4%
Singapore 1 2%
Unknown 51 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 13%
Student > Bachelor 6 11%
Student > Postgraduate 5 9%
Other 4 7%
Student > Ph. D. Student 4 7%
Other 12 22%
Unknown 16 30%
Readers by discipline Count As %
Medicine and Dentistry 19 35%
Biochemistry, Genetics and Molecular Biology 2 4%
Agricultural and Biological Sciences 2 4%
Nursing and Health Professions 2 4%
Engineering 2 4%
Other 5 9%
Unknown 22 41%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 September 2023.
All research outputs
#2,203,524
of 25,481,734 outputs
Outputs from Arthritis Research & Therapy
#400
of 3,390 outputs
Outputs of similar age
#14,051
of 186,293 outputs
Outputs of similar age from Arthritis Research & Therapy
#5
of 41 outputs
Altmetric has tracked 25,481,734 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,390 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 186,293 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.