Title |
Pathogenesis of tendinopathies: inflammation or degeneration?
|
---|---|
Published in |
Arthritis Research & Therapy, June 2009
|
DOI | 10.1186/ar2723 |
Pubmed ID | |
Authors |
Michele Abate, Karin Gravare Silbernagel, Carl Siljeholm, Angelo Di Iorio, Daniele De Amicis, Vincenzo Salini, Suzanne Werner, Roberto Paganelli |
Abstract |
The intrinsic pathogenetic mechanisms of tendinopathies are largely unknown and whether inflammation or degeneration has the prominent role is still a matter of debate. Assuming that there is a continuum from physiology to pathology, overuse may be considered as the initial disease factor; in this context, microruptures of tendon fibers occur and several molecules are expressed, some of which promote the healing process, while others, including inflammatory cytokines, act as disease mediators. Neural in-growth that accompanies the neovessels explains the occurrence of pain and triggers neurogenic-mediated inflammation. It is conceivable that inflammation and degeneration are not mutually exclusive, but work together in the pathogenesis of tendinopathies. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 8 | 11% |
United Kingdom | 7 | 10% |
United States | 4 | 6% |
Germany | 2 | 3% |
Canada | 2 | 3% |
Brazil | 2 | 3% |
Netherlands | 1 | 1% |
Finland | 1 | 1% |
Italy | 1 | 1% |
Other | 11 | 15% |
Unknown | 33 | 46% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 57 | 79% |
Scientists | 11 | 15% |
Practitioners (doctors, other healthcare professionals) | 4 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 5 | <1% |
Brazil | 3 | <1% |
United States | 2 | <1% |
Spain | 2 | <1% |
Austria | 2 | <1% |
Italy | 2 | <1% |
Portugal | 1 | <1% |
Cyprus | 1 | <1% |
Norway | 1 | <1% |
Other | 3 | <1% |
Unknown | 797 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 120 | 15% |
Student > Bachelor | 120 | 15% |
Student > Ph. D. Student | 81 | 10% |
Researcher | 65 | 8% |
Other | 61 | 7% |
Other | 174 | 21% |
Unknown | 198 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 268 | 33% |
Nursing and Health Professions | 90 | 11% |
Sports and Recreations | 84 | 10% |
Agricultural and Biological Sciences | 37 | 5% |
Engineering | 27 | 3% |
Other | 79 | 10% |
Unknown | 234 | 29% |