You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Modeling Alexander disease with patient iPSCs reveals cellular and molecular pathology of astrocytes
|
|---|---|
| Published in |
Acta Neuropathologica Communications, July 2016
|
| DOI | 10.1186/s40478-016-0337-0 |
| Pubmed ID | |
| Authors |
Takayuki Kondo, Misato Funayama, Michiyo Miyake, Kayoko Tsukita, Takumi Era, Hitoshi Osaka, Takashi Ayaki, Ryosuke Takahashi, Haruhisa Inoue |
| Abstract |
Alexander disease is a fatal neurological illness characterized by white-matter degeneration and formation of Rosenthal fibers, which contain glial fibrillary acidic protein as astrocytic inclusion. Alexander disease is mainly caused by a gene mutation encoding glial fibrillary acidic protein, although the underlying pathomechanism remains unclear. We established induced pluripotent stem cells from Alexander disease patients, and differentiated induced pluripotent stem cells into astrocytes. Alexander disease patient astrocytes exhibited Rosenthal fiber-like structures, a key Alexander disease pathology, and increased inflammatory cytokine release compared to healthy control. These results suggested that Alexander disease astrocytes contribute to leukodystrophy and a variety of symptoms as an inflammatory source in the Alexander disease patient brain. Astrocytes, differentiated from induced pluripotent stem cells of Alexander disease, could be a cellular model for future translational medicine. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 33% |
| United States | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 67 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 17 | 25% |
| Student > Ph. D. Student | 9 | 13% |
| Student > Master | 6 | 9% |
| Other | 5 | 7% |
| Student > Doctoral Student | 4 | 6% |
| Other | 11 | 16% |
| Unknown | 15 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 17 | 25% |
| Agricultural and Biological Sciences | 12 | 18% |
| Medicine and Dentistry | 10 | 15% |
| Biochemistry, Genetics and Molecular Biology | 6 | 9% |
| Unspecified | 2 | 3% |
| Other | 4 | 6% |
| Unknown | 16 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 December 2017.
All research outputs
#14,268,471
of 22,880,691 outputs
Outputs from Acta Neuropathologica Communications
#1,076
of 1,379 outputs
Outputs of similar age
#204,774
of 354,317 outputs
Outputs of similar age from Acta Neuropathologica Communications
#23
of 32 outputs
Altmetric has tracked 22,880,691 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,379 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.8. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 354,317 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.