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Activity of crude extracts from Brazilian cerrado plants against clinically relevant Candida species

Overview of attention for article published in BMC Complementary Medicine and Therapies, July 2016
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Title
Activity of crude extracts from Brazilian cerrado plants against clinically relevant Candida species
Published in
BMC Complementary Medicine and Therapies, July 2016
DOI 10.1186/s12906-016-1164-3
Pubmed ID
Authors

Amabel Fernandes Correia, Dâmaris Silveira, Yris Maria Fonseca-Bazzo, Pérola Oliveira Magalhães, Christopher William Fagg, Elton Clementino da Silva, Suelí Maria Gomes, Lenora Gandolfi, Riccardo Pratesi, Yanna Karla de Medeiros Nóbrega

Abstract

Medicinal plants have traditionally been used in many parts of the world as alternative medicine. Many extracts and essential oils isolated from plants have disclosed biological activity, justifying the investigation of their potential antimicrobial activity. In this study, the in vitro antifungal activity of six Brazilian Cerrado medicinal plant species were evaluated against clinically relevant Candida species. The crude extract plants were evaluated against American Type Culture Collection (ATCC) standard strains of Candida spp. using disk diffusion method and determining the minimum inhibitory concentration (MIC). The chemical study results were confirmed by HPLC method. All six plant species showed antifungal activity. Among the species studied, Eugenia dysenterica and Pouteria ramiflora showed significant inhibitory activity against C. tropicalis at lowest MIC value of 125 and 500 μg/disc, respectively. The Eugenia dysenterica also disclosed MIC value of 125 μg/disc against C. famata, 250 μg/disc against C. krusei and 500 μg/disc against C. guilliermondii and C. parapsilosis. Pouteria torta, Bauhinia rufa, Erythroxylum daphnites and Erythroxylum subrotundum showed activity against the yeast strains with MIC value of 1000 μg/disc. The chemical study of the most bioactive extracts of Eugenia dysenterica and Pouteria ramiflora revealed catechin derivatives and flavonoids as main components. All six evaluated plant species showed good antifungal potential against several Candida strains. However, E .dysenterica and P. ramiflora showed the higher inhibitory effect against the non-albicans Candida species. Our results may contribute to the continuing search of new natural occurring products with antifungal activity.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 2%
Unknown 84 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 17 20%
Student > Bachelor 16 19%
Student > Doctoral Student 10 12%
Student > Postgraduate 5 6%
Professor 4 5%
Other 12 14%
Unknown 22 26%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 19%
Medicine and Dentistry 10 12%
Pharmacology, Toxicology and Pharmaceutical Science 7 8%
Biochemistry, Genetics and Molecular Biology 7 8%
Chemistry 7 8%
Other 16 19%
Unknown 23 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2016.
All research outputs
#18,465,988
of 22,880,691 outputs
Outputs from BMC Complementary Medicine and Therapies
#2,518
of 3,637 outputs
Outputs of similar age
#270,858
of 354,317 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#68
of 103 outputs
Altmetric has tracked 22,880,691 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,637 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 354,317 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 103 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.