Title |
Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment
|
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Published in |
Genome Biology, September 2012
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DOI | 10.1186/gb-2012-13-9-r79 |
Pubmed ID | |
Authors |
Xochitl C Morgan, Timothy L Tickle, Harry Sokol, Dirk Gevers, Kathryn L Devaney, Doyle V Ward, Joshua A Reyes, Samir A Shah, Neal LeLeiko, Scott B Snapper, Athos Bousvaros, Joshua Korzenik, Bruce E Sands, Ramnik J Xavier, Curtis Huttenhower |
Abstract |
The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis result from alterations in intestinal microbes and the immune system. However, the precise dysfunctions of microbial metabolism in the gastrointestinal microbiome during IBD remain unclear. We analyzed the microbiota of intestinal biopsies and stool samples from 231 IBD and healthy subjects by 16S gene pyrosequencing and followed up a subset using shotgun metagenomics. Gene and pathway composition were assessed, based on 16S data from phylogenetically-related reference genomes, and associated using sparse multivariate linear modeling with medications, environmental factors, and IBD status. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 14% |
United States | 3 | 14% |
Brazil | 1 | 5% |
Grenada | 1 | 5% |
France | 1 | 5% |
India | 1 | 5% |
Spain | 1 | 5% |
Unknown | 10 | 48% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 16 | 76% |
Scientists | 3 | 14% |
Science communicators (journalists, bloggers, editors) | 2 | 10% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 41 | 2% |
Canada | 7 | <1% |
Netherlands | 5 | <1% |
United Kingdom | 5 | <1% |
Germany | 3 | <1% |
Denmark | 3 | <1% |
Brazil | 3 | <1% |
Spain | 2 | <1% |
Australia | 1 | <1% |
Other | 12 | <1% |
Unknown | 2067 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 449 | 21% |
Researcher | 377 | 18% |
Student > Master | 267 | 12% |
Student > Bachelor | 222 | 10% |
Student > Doctoral Student | 95 | 4% |
Other | 320 | 15% |
Unknown | 419 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 569 | 26% |
Medicine and Dentistry | 315 | 15% |
Biochemistry, Genetics and Molecular Biology | 291 | 14% |
Immunology and Microbiology | 189 | 9% |
Computer Science | 41 | 2% |
Other | 240 | 11% |
Unknown | 504 | 23% |