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Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment

Overview of attention for article published in Genome Biology, September 2012
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Citations

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2190 Dimensions

Readers on

mendeley
2149 Mendeley
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6 CiteULike
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Title
Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment
Published in
Genome Biology, September 2012
DOI 10.1186/gb-2012-13-9-r79
Pubmed ID
Authors

Xochitl C Morgan, Timothy L Tickle, Harry Sokol, Dirk Gevers, Kathryn L Devaney, Doyle V Ward, Joshua A Reyes, Samir A Shah, Neal LeLeiko, Scott B Snapper, Athos Bousvaros, Joshua Korzenik, Bruce E Sands, Ramnik J Xavier, Curtis Huttenhower

Abstract

The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis result from alterations in intestinal microbes and the immune system. However, the precise dysfunctions of microbial metabolism in the gastrointestinal microbiome during IBD remain unclear. We analyzed the microbiota of intestinal biopsies and stool samples from 231 IBD and healthy subjects by 16S gene pyrosequencing and followed up a subset using shotgun metagenomics. Gene and pathway composition were assessed, based on 16S data from phylogenetically-related reference genomes, and associated using sparse multivariate linear modeling with medications, environmental factors, and IBD status.

X Demographics

X Demographics

The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 2,149 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 41 2%
Canada 7 <1%
Netherlands 5 <1%
United Kingdom 5 <1%
Germany 3 <1%
Denmark 3 <1%
Brazil 3 <1%
Spain 2 <1%
Australia 1 <1%
Other 12 <1%
Unknown 2067 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 449 21%
Researcher 377 18%
Student > Master 267 12%
Student > Bachelor 222 10%
Student > Doctoral Student 95 4%
Other 320 15%
Unknown 419 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 569 26%
Medicine and Dentistry 315 15%
Biochemistry, Genetics and Molecular Biology 291 14%
Immunology and Microbiology 189 9%
Computer Science 41 2%
Other 240 11%
Unknown 504 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 67. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 May 2023.
All research outputs
#648,287
of 25,711,518 outputs
Outputs from Genome Biology
#398
of 4,505 outputs
Outputs of similar age
#3,423
of 191,454 outputs
Outputs of similar age from Genome Biology
#2
of 55 outputs
Altmetric has tracked 25,711,518 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,505 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 191,454 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.